State Key Laboratory of Veterinary Biotechnology-Harbin Veterinary Research Institute, CAAS, Harbin, China.
Department of Fundamental Veterinary Medicine, College of Animal Science and Veterinary Medicine-Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Shandong, China.
Vet Microbiol. 2018 Feb;214:1-6. doi: 10.1016/j.vetmic.2017.11.033. Epub 2017 Nov 27.
Equine influenza virus is a major respiratory pathogen in horses. Although both horses and donkeys belong to the genus Equus, donkey infection with influenza viruses is rare. In March 2017, an influenza outbreak occurred in donkeys in Shandong province, China. The causative virus, A/donkey/Shandong/1/2017(H3N8), was isolated from a dead donkey. Genetic analysis indicated that the virus originated from influenza A (H3N8) clade 2 of the Florida sub-lineage that has been circulating in Asian equine populations. Comparison of the deduced amino acid sequence of the HA gene of this causative virus with that of the A/equine/Richmond/1/2007 vaccine strain showed that substitutions had occurred in the antigenic regions A, B, and C. This study provides insight into the currently circulating and newly emerging H3N8 strains in donkeys in China.
马流感病毒是马的主要呼吸道病原体。尽管马和驴都属于马属，但驴感染流感病毒的情况很少见。2017 年 3 月，中国山东省的驴群中发生了一次流感疫情。从一只死亡的驴中分离出了引起此次疫情的病毒，A/donkey/Shandong/1/2017(H3N8)。遗传分析表明，该病毒源自在亚洲马群中流行的佛罗里达亚系 2 分支的流感 A(H3N8)。与 A/equine/Richmond/1/2007 疫苗株的 HA 基因推导的氨基酸序列比较表明，抗原区域 A、B 和 C 发生了突变。本研究为了解目前在中国流行和新出现的 H3N8 毒株提供了线索。
