Maxwell Colleen J, Dalby Dawn M, Slater Morgan, Patten Scott B, Hogan David B, Eliasziw Michael, Hirdes John P
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB, Canada T2N 4N1 Department of Medicine, University of Calgary, Calgary, AB, Canada Department of Psychiatry, University of Calgary, Calgary, AB, Canada Institute of Health Economics, Edmonton, AB, Canada Department of Kinesiology & Physical Education, Wilfrid Laurier University, Waterloo, Ont., Canada Department of Health Studies & Gerontology, University of Waterloo, Waterloo, Ont., Canada Homewood Research Institute, Guelph, Ont., Canada.
Pain. 2008 Aug 15;138(1):208-216. doi: 10.1016/j.pain.2008.04.007. Epub 2008 May 29.
The aim of this cross-sectional study was to examine the prevalence and correlates of pharmacotherapy for current daily pain in older home care clients, focusing on analgesic type and potential contraindications to treatment. The sample included 2779 clients aged 65+years receiving services from Community Care Access Centres in Ontario during 1999-2001. Clients were assessed with the Resident Assessment Instrument-Home Care (RAI-HC). Prescription and over-the-counter (OTC) medications listed on the RAI-HC were used to categorize analgesic treatment into two groups (relative to no analgesic use): use of non-opioids (acetaminophen or non-steroidal anti-inflammatory drugs only); and, use of opioids alone or in combination with non-opioids. Associations between client characteristics and analgesic treatment among those in current daily pain were examined using multivariable multinomial logistic regression. Approximately 48% (n=1,329) of clients had daily pain and one-fifth (21.6%) of this group received no analgesic. In multivariable analyses, clients aged 75+years and those with congestive heart failure, diabetes, other disease-related contraindications, cognitive impairment and/or requiring an interpreter were significantly less likely to receive an opioid alone or in combination with a non-opioid. Clients with congestive heart failure and without a diagnosis of arthritis were significantly less likely to receive a non-opioid alone. A diagnosis of arthritis or cancer and use of nine or more medications were significantly associated with opioid use. The findings provide evidence of both rational prescribing practices and potential treatment bias in the pharmacotherapeutic management of daily pain in older home care clients.
这项横断面研究的目的是调查老年居家护理患者当前日常疼痛药物治疗的患病率及其相关因素,重点关注镇痛药物类型和潜在治疗禁忌证。样本包括1999年至2001年期间在安大略省社区护理接入中心接受服务的2779名65岁及以上的患者。使用居民评估工具-居家护理(RAI-HC)对患者进行评估。RAI-HC上列出的处方药和非处方药被用于将镇痛治疗分为两组(相对于未使用镇痛药物):使用非阿片类药物(仅对乙酰氨基酚或非甾体类抗炎药);以及单独使用阿片类药物或与非阿片类药物联合使用。使用多变量多项逻辑回归分析当前日常疼痛患者的特征与镇痛治疗之间的关联。约48%(n = 1329)的患者有日常疼痛,其中五分之一(21.6%)的患者未接受任何镇痛治疗。在多变量分析中,75岁及以上的患者以及患有充血性心力衰竭、糖尿病、其他疾病相关禁忌证、认知障碍和/或需要翻译的患者单独使用阿片类药物或与非阿片类药物联合使用的可能性显著降低。患有充血性心力衰竭且未诊断出关节炎的患者单独使用非阿片类药物的可能性显著降低。关节炎或癌症的诊断以及使用九种或更多药物与阿片类药物的使用显著相关。这些发现为老年居家护理患者日常疼痛的药物治疗管理中的合理处方实践和潜在治疗偏差提供了证据。