叙利亚仓鼠：一种用于研究肠道毒素激发后肠液分泌变化的可重复性模型。
The Syrian hamster: a reproducible model for studying changes in intestinal fluid secretion in response to enterotoxin challenge.
作者信息
Lepot A, Banwell J G
出版信息
Infect Immun. 1976 Nov;14(5):1167-71. doi: 10.1128/iai.14.5.1167-1171.1976.
Abstract
Syrian hamsters respond in a predictable and reproducible manner to intragastric administration of purified cholera enterotoxin by intraluminal accumulation of fluid in the small bowel, cecum, and proximal colon. In the majority of animals this process is self limiting, and recovery occurs with full reabsorption of intestinal fluid by 30 to 35 h. The secretory response to 75 mug of cholera toxin has been defined, and the model was utilized to study the inhibitory effects of indomethacin, polymyxin B sulfate, glucose electrolyte solutions, and colchicine. These studies demonstrate its potential usefulness as a convenient and inexpensive technique for evaluation of pharmacological agents that might inhibit intestinal fluid secretion.
摘要
叙利亚仓鼠对经胃内给予纯化的霍乱肠毒素会产生可预测且可重复的反应，表现为小肠、盲肠和近端结肠内液体的腔内积聚。在大多数动物中，这个过程是自限性的，到30至35小时时肠道液体完全重吸收，动物恢复。对75微克霍乱毒素的分泌反应已明确，该模型被用于研究吲哚美辛、硫酸多粘菌素B、葡萄糖电解质溶液和秋水仙碱的抑制作用。这些研究证明了它作为一种方便且廉价的技术在评估可能抑制肠道液体分泌的药物制剂方面的潜在用途。
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