肺部疾病中的淋巴管
Lymphatics in lung disease.
作者信息
El-Chemaly Souheil, Levine Stewart J, Moss Joel
机构信息
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg. 10, Rm 6D03, MSC 1590, Bethesda, MD 20892-1590, USA.
出版信息
Ann N Y Acad Sci. 2008;1131:195-202. doi: 10.1196/annals.1413.017.
Abstract
The lymphatic circulation appears to be a vital component in lung biology in health and in disease. Animal models have established the role of the lymphatic circulation in neoplastic and inflammatory diseases of the lung, such as asthma and cancer, and allowed for the understanding of the molecular controls of lymphangiogenesis in normal lung development. Understanding the role of lymphatics in human lung disease appears likely to contribute to the understanding of the pathogenesis of disease and the development of novel therapeutic targets.
摘要
淋巴循环似乎是健康和疾病状态下肺生物学的一个重要组成部分。动物模型已证实淋巴循环在肺部肿瘤性和炎症性疾病（如哮喘和癌症）中的作用，并有助于理解正常肺发育过程中淋巴管生成的分子调控机制。了解淋巴管在人类肺部疾病中的作用可能有助于理解疾病的发病机制并开发新的治疗靶点。
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