Lu Peng, Chen Xiaoming, Liu Xuyang, Yu Ling, Kang Ying, Xie Quanhua, Ke Lang, Wei Xiaoyan
Ophthalmology Department, West China Hospital, Sichuan University, Chengdu, China.
Cornea. 2008 Jun;27(5):545-51. doi: 10.1097/ICO.0b013e318165b1b7.
To determine the prevalence of dry eye syndrome, analyze the relationship between dry eye symptoms and signs, and identify associated risk factors for dry eye syndrome in an elderly Tibetan population at high altitude.
A population-based survey was conducted from October 2006 to December 2006. A stratified, clustered, random sampling procedure was used to select 2632 native Tibetan people >or=40 years of age. Symptoms of dry eye were assessed by using a 6-item validated questionnaire. Dry eye syndrome was diagnosed in those subjects having 1 or more symptoms often or all the time. Positive signs included a tear film breakup time of <or=10 seconds in 1 or both eyes, a Schirmer test score of <or=5 mm, or a fluorescein score of >or=1. Correlations between symptoms and signs were analyzed.
Of a total of 2632 eligible subjects, 2229 (84.69%) were examined. The data of 1840 participants were analyzed. Of 1840 participants, 52.4% (95% confidence interval: 50.2-54.7) were symptomatic. The tear film breakup time of <or=10 seconds was seen in 35.3% (95% confidence interval: 33.1-37.5), a Schirmer test score of <or= 5 mm was seen in 24.7% (95% confidence interval: 22.8-26.7), and a fluorescein score of >or=1 was seen in 5.8% (95% confidence interval: 4.7-6.9). The correlations between dry eye symptoms and signs were statistically significant. Independent risk factors for dry eye syndrome were positive dry eye signs, increased age, low education level and socioeconomic status, and higher altitude.
This study shows a high prevalence rate of dry eye syndrome in elderly Tibetans, representing an important health problem.
确定高原地区老年藏族人群中干眼综合征的患病率，分析干眼症状与体征之间的关系，并识别干眼综合征的相关危险因素。
于2006年10月至2006年12月进行了一项基于人群的调查。采用分层、整群、随机抽样方法选取2632名年龄≥40岁的藏族原住民。使用一份经过验证的6项问卷评估干眼症状。在那些经常或一直有1种或更多症状的受试者中诊断为干眼综合征。阳性体征包括一只或两只眼睛的泪膜破裂时间≤10秒、泪液分泌试验评分≤5毫米或荧光素评分≥1。分析症状与体征之间的相关性。
在总共2632名符合条件的受试者中，2229名（84.69%）接受了检查。对1840名参与者的数据进行了分析。在1840名参与者中，52.4%（95%置信区间：50.2 - 54.7）有症状。泪膜破裂时间≤10秒的占35.3%（95%置信区间：33.1 - 37.5），泪液分泌试验评分≤5毫米的占24.7%（95%置信区间：22.8 - 26.7），荧光素评分≥1的占5.8%（95%置信区间：4.7 - 6.9）。干眼症状与体征之间的相关性具有统计学意义。干眼综合征的独立危险因素为干眼阳性体征、年龄增加、教育水平和社会经济地位低以及海拔较高。
本研究表明老年藏族人群中干眼综合征患病率较高，这是一个重要的健康问题。
