Hanus Cyril, Ehlers Michael D
Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Traffic. 2008 Sep;9(9):1437-45. doi: 10.1111/j.1600-0854.2008.00775.x. Epub 2008 Jun 4.
The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.
神经元树突的巨大尺寸和几何复杂性需要专门的机制，以便在较长距离上输送突触后货物，并在亚微米尺度上调节树突的组成。尽管膜运输在树突生长、突触形成和可塑性方面具有根本重要性，但控制突触后运输的细胞器和细胞规则才刚刚开始显现。在这里，我们综述了目前已知的关于树突分泌细胞器及其在突触后区室的发育、维持和可塑性中的作用。
