Slater Bethany J, Kwan Matthew D, Gupta Deepak M, Panetta Nicholas J, Longaker Michael T
Stanford University School of Medicine, Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, 257 Campus Drive, Stanford, CA 94305-5148, USA.
Expert Opin Biol Ther. 2008 Jul;8(7):885-93. doi: 10.1517/14712598.8.7.885.
Skeletal defects represent a significant socioeconomic burden to the US healthcare system. Current options for reconstructing osseous deficits have shortcomings.
To review the use of mesenchymal stem cells for skeletal tissue engineering.
We focused on the application of mesenchymal cells in skeletal regeneration, optimization of this technique, tropic effects of multipotent mesenchymal cells, and future directions.
RESULTS/CONCLUSION: A number of cell-based modalities have been investigated. We have been interested in the role of adipose-derived stromal cells in bone regeneration and understanding the mechanisms behind osteogenic differentiation of progenitor cells and acceleration of this process. Future clinical applications of multipotent mesenchymal cells will depend on better understanding of the molecular signaling involved in osteogenic differentiation and maintaining pluripotency.
骨骼缺陷给美国医疗系统带来了巨大的社会经济负担。目前用于重建骨缺损的方法存在缺陷。
综述间充质干细胞在骨骼组织工程中的应用。
我们重点关注间充质细胞在骨骼再生中的应用、该技术的优化、多能间充质细胞的趋化作用以及未来方向。
结果/结论：已经研究了多种基于细胞的方法。我们一直关注脂肪来源的基质细胞在骨再生中的作用，并了解祖细胞成骨分化背后的机制以及加速这一过程。多能间充质细胞未来的临床应用将取决于对成骨分化和维持多能性所涉及的分子信号有更好的理解。
