Zakrzewski Wojciech, Dobrzynski Maciej, Rybak Zbigniew, Szymonowicz Maria, Wiglusz Rafal J
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland.
Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
Nanomaterials (Basel). 2020 Jun 22;10(6):1216. doi: 10.3390/nano10061216.
Regenerative properties are different in every human tissue. Nowadays, with the increasing popularity of dental implants, bone regenerative procedures called augmentations are sometimes crucial in order to perform a successful dental procedure. Tissue engineering allows for controlled growth of alveolar and periodontal tissues, with use of scaffolds, cells, and signalling molecules. By modulating the patient's tissues, it can positively influence poor integration and healing, resulting in repeated implant surgeries. Application of nanomaterials and stem cells in tissue regeneration is a newly developing field, with great potential for maxillofacial bony defects. Nanostructured scaffolds provide a closer structural support with natural bone, while stem cells allow bony tissue regeneration in places when a certain volume of bone is crucial to perform a successful implantation. Several types of selected nanomaterials and stem cells were discussed in this study. Their use has a high impact on the efficacy of the current and future procedures, which are still challenging for medicine. There are many factors that can influence the regenerative process, while its general complexity makes the whole process even harder to control. The aim of this study was to evaluate the effectiveness and advantage of both stem cells and nanomaterials in order to better understand their function in regeneration of bone tissue in oral cavity.
人体的每一种组织都有不同的再生特性。如今，随着种植牙越来越普及，为了成功实施牙科手术，一种名为骨增量的骨再生手术有时至关重要。组织工程学利用支架、细胞和信号分子实现牙槽组织和牙周组织的可控生长。通过调节患者的组织，它可以对不良的整合与愈合产生积极影响，从而避免反复进行种植手术。纳米材料和干细胞在组织再生中的应用是一个新兴领域，在治疗颌面骨缺损方面具有巨大潜力。纳米结构支架能提供与天然骨更接近的结构支撑，而干细胞则能在一定骨量对成功植入至关重要的部位实现骨组织再生。本研究讨论了几种选定的纳米材料和干细胞。它们的应用对当前及未来手术的疗效有很大影响，而这些手术对医学来说仍然具有挑战性。有许多因素会影响再生过程，而其总体复杂性使得整个过程更难控制。本研究的目的是评估干细胞和纳米材料的有效性及优势，以便更好地了解它们在口腔骨组织再生中的作用。
