运动冻结心肌灌注单光子发射计算机断层扫描可提高肥胖患者冠状动脉疾病的检测率。
Motion-frozen myocardial perfusion SPECT improves detection of coronary artery disease in obese patients.
作者信息
Suzuki Yasuyuki, Slomka Piotr J, Wolak Arik, Ohba Muneo, Suzuki Shoji, De Yang Ling, Germano Guido, Berman Daniel S
机构信息
Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
出版信息
J Nucl Med. 2008 Jul;49(7):1075-9. doi: 10.2967/jnumed.108.050997. Epub 2008 Jun 13.
UNLABELLED
In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients.
METHODS
A total of 90 consecutive obese patients (body mass index, 30.1-46.8, average, 34.3 +/- 3.6; age, 63 +/- 12 y; 30% women) underwent standard supine rest (201)Tl/stress (99m)Tc dual-isotope gated MPS and cardiac catheterization within 3 mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits.
RESULTS
The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 +/- 0.25 vs. 0.88 +/- 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD.
CONCLUSION
MF processing of MPS improves CAD detection in obese patients.
未标注
在本研究中，我们比较了标准单光子发射计算机断层扫描（SPECT）与运动冻结（MF）心肌灌注SPECT（MPS）在肥胖患者中的诊断性能。
方法
连续90例肥胖患者（体重指数，30.1 - 46.8，平均34.3±3.6；年龄，63±12岁；30%为女性）在3个月内接受标准仰卧位静息（201）铊/负荷（99m）锝双同位素门控MPS和心脏导管检查。通过将心脏相位非线性扭曲到舒张末期位置获得MF图像。使用性别特异性标准和MF正常范围，对总和（S - TPD）和运动冻结（MF - TPD）数据集获得总灌注缺损（TPD）。
结果
通过MF - TPD检测冠状动脉疾病（CAD）的受试者操作特征（ROC）曲线下面积显著大于S - TPD（0.93±0.25对0.88±0.32，P <
0.05）。MF - TPD比S - TPD具有更高的特异性（77%对55%，P < 0.05）和准确性（89%对80%，P < 0.05）。
结论
MPS的MF处理可改善肥胖患者CAD的检测。
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