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His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7.组氨酸224改变了R2药物结合位点，苯丙氨酸218影响金属β-内酰胺酶VIM-7的催化效率。
Antimicrob Agents Chemother. 2014 Aug;58(8):4826-36. doi: 10.1128/AAC.02735-13. Epub 2014 Jun 9.
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Genetic and biochemical characterization of an acquired subgroup B3 metallo-β-lactamase gene, blaAIM-1, and its unique genetic context in Pseudomonas aeruginosa from Australia.澳大利亚铜绿假单胞菌获得性亚群 B3 金属β-内酰胺酶基因 blaAIM-1 的遗传和生化特征及其独特的遗传环境。
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本文引用的文献

1
The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form.来自铜绿假单胞菌的锌β-内酰胺酶VIM-2还原态和氧化态的三维结构。
J Mol Biol. 2008 Jan 18;375(3):604-11. doi: 10.1016/j.jmb.2007.11.012. Epub 2007 Nov 13.
2
Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.铜绿假单胞菌SPM-1的晶体结构为金属β-内酰胺酶可变锌亲和力提供了见解。
J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23.
3
Hydroxyl groups in the (beta)beta sandwich of metallo-beta-lactamases favor enzyme activity: a computational protein design study.金属β-内酰胺酶β折叠中的羟基有利于酶活性：一项计算蛋白设计研究。
J Mol Biol. 2005 Jul 15;350(3):395-401. doi: 10.1016/j.jmb.2005.04.044.
4
Metallo-beta-lactamases: the quiet before the storm?金属β-内酰胺酶：暴风雨前的宁静？
Clin Microbiol Rev. 2005 Apr;18(2):306-25. doi: 10.1128/CMR.18.2.306-325.2005.
5
Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance.远程突变对金属β-内酰胺酶底物特异性的影响：对抗生素耐药性进化的启示。
Protein Sci. 2005 Mar;14(3):765-74. doi: 10.1110/ps.041093405.
6
blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.blaVIM-7，一种来自美国一株铜绿假单胞菌分离株中进化上独特的金属β-内酰胺酶基因。
Antimicrob Agents Chemother. 2004 Jan;48(1):329-32. doi: 10.1128/AAC.48.1.329-332.2004.
7
Evolution of an integron carrying blaVIM-2 in Eastern Europe: report from the SENTRY Antimicrobial Surveillance Program.东欧携带blaVIM-2整合子的进化：哨兵抗菌监测计划报告
J Antimicrob Chemother. 2003 Jul;52(1):116-9. doi: 10.1093/jac/dkg299. Epub 2003 Jun 12.
8
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases.关于VIM型金属β-内酰胺酶的功能和结构异质性
J Antimicrob Chemother. 2003 Feb;51(2):257-66. doi: 10.1093/jac/dkg067.
9
Biochemical characterization of the acquired metallo-beta-lactamase SPM-1 from Pseudomonas aeruginosa.铜绿假单胞菌获得性金属β-内酰胺酶SPM-1的生化特性
Antimicrob Agents Chemother. 2003 Feb;47(2):582-7. doi: 10.1128/AAC.47.2.582-587.2003.
10
ESyPred3D: Prediction of proteins 3D structures.ESyPred3D：蛋白质三维结构预测
Bioinformatics. 2002 Sep;18(9):1250-6. doi: 10.1093/bioinformatics/18.9.1250.

VIM金属β-内酰胺酶家族的一个不同成员VIM-7的动力学特征

Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.

作者信息

Samuelsen Ørjan, Castanheira Mariana, Walsh Timothy R, Spencer James

机构信息

Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, 9038 Tromsø, Norway.

出版信息

Antimicrob Agents Chemother. 2008 Aug;52(8):2905-8. doi: 10.1128/AAC.00166-08. Epub 2008 Jun 16.

DOI:10.1128/AAC.00166-08
PMID:18559652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493091/
Abstract

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

摘要

纯化的重组VIM-7具有与VIM-2相当的高效青霉素酶和碳青霉烯酶活性。头孢菌素酶活性存在差异，通常低于VIM-1和VIM-2。同源模型表明，VIM-7的酪氨酸218被苯丙氨酸取代可能是导致其对某些头孢菌素（包括头孢他啶和头孢吡肟）催化效率降低的原因。