Addams-Williams J, Watkins D, Owen S, Williams N, Fielder C
Department of Otorhinolaryngology, Head and Neck Surgery, Singleton Hospital, Swansea NHS Trust, Sketty, Swansea, UK.
Eur Arch Otorhinolaryngol. 2009 Mar;266(3):411-5. doi: 10.1007/s00405-008-0751-4. Epub 2008 Jun 24.
To compare the non-diagnostic rate of fine needle aspiration cytology (FNAC) of non-thyroid neck lumps performed under ultrasound (US) guidance against non-guided FNAC (performed in outpatient clinic). Final histology results were compared with cytological diagnosis. We performed a retrospective study of 625 patients identified as having undergone FNAC of non-thyroid neck lumps from the pathology/radiology databases over a 3 year period. A total of 396 patients underwent non-ultrasound guided FNAC (12 excluded). 34% of patients had a non-diagnostic sample. A total number of 229 patients underwent ultrasound guided FNAC with a non-diagnostic rate of 12%. The Chi-squared test showed a significant difference (P < 0.001). FNAC results were compared with definitive histology in 238 patients. Sensitivity was 92% and specificity was 90%. US-guided FNAC resulted in a lower non-diagnostic rate. FNAC was highly sensitive for diagnosis of malignant lumps but less good at confirming a lump to be benign.
比较在超声（US）引导下对非甲状腺颈部肿块进行细针穿刺抽吸细胞学检查（FNAC）与非引导下FNAC（在门诊进行）的非诊断率。将最终组织学结果与细胞学诊断进行比较。我们对3年内从病理/放射学数据库中确定的625例接受非甲状腺颈部肿块FNAC检查的患者进行了回顾性研究。共有396例患者接受了非超声引导下的FNAC（排除12例）。34%的患者样本为非诊断性。共有229例患者接受了超声引导下的FNAC，非诊断率为12%。卡方检验显示差异有统计学意义（P<0.001）。对238例患者的FNAC结果与最终组织学结果进行了比较。敏感性为92%，特异性为90%。超声引导下的FNAC导致较低的非诊断率。FNAC对恶性肿块的诊断高度敏感，但在确认肿块为良性方面效果较差。
