Akhavan-Moghadam Jamal, Afaaghi Mahdi, Maleki Ali Reza, Saburi Amin
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran ; Department of Surgery, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran ; Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, IR Iran.
Trauma Mon. 2013 Dec;18(3):117-21. doi: 10.5812/traumamon.10541. Epub 2013 Oct 13.
Patients presenting with a mass require tissue biopsy for histological diagnosis and treatment. Fine needle aspiration (FNA) is offered as an atraumatic, well tolerated, and inexpensive method for obtaining a biopsy from these lesions.
In this study we evaluated the accuracy of FNA as an atraumatic method among patients with nonthyroidal masses for diagnosis of neoplastic masses compared to open surgery.
In a cross-sectional study, 65 patients with a head and neck masses (nonthyroidal) referred to us from 2004 to 2009. Those who had both FNA and open biopsy (the gold standard) were assessed for specificity, sensitivity, positive and negative predictive values of FNA in diagnoses.
Sixty-five cases with both definite diagnoses of open biopsy and FNA were assessed. The mean (± standard deviation) age of patients was 39.96 ± 19.69 years (range 10 to 82 years). Twenty-five (40.8%) subjects were categorized as malignant neoplasms, 16 (19.4%) as benign neoplasms, and 24 (39.8%) as non-neoplastic lesions. The sensitivity, specificity, positive and also negative predictive values of FNA in the diagnosis of neoplastic masses were 95%, 85%, 92.68%, and 91.66% respectively, and the diagnostic accuracy was 92.3%.
It seems that FNA is a useful atraumatic diagnostic technique with a high diagnostic accuracy which can provide a highly sensitive diagnosis with low false positive diagnoses in patients with nonthyroidal masses.
出现肿块的患者需要进行组织活检以进行组织学诊断和治疗。细针穿刺抽吸活检（FNA）是一种用于从这些病变获取活检的无创、耐受性良好且成本低廉的方法。
在本研究中，我们评估了FNA作为一种无创方法在非甲状腺肿块患者中诊断肿瘤性肿块相对于开放手术的准确性。
在一项横断面研究中，2004年至2009年期间，65例头颈部（非甲状腺）肿块患者转诊至我们处。对那些同时进行了FNA和开放活检（金标准）的患者评估FNA诊断的特异性、敏感性、阳性和阴性预测值。
对65例同时有开放活检和FNA明确诊断的病例进行了评估。患者的平均（±标准差）年龄为39.96±19.69岁（范围10至82岁）。25例（40.8%）受试者被归类为恶性肿瘤，16例（19.4%）为良性肿瘤，24例（39.8%）为非肿瘤性病变。FNA诊断肿瘤性肿块的敏感性、特异性、阳性和阴性预测值分别为95%、85%、92.68%和91.66%，诊断准确性为92.3%。
FNA似乎是一种有用的无创诊断技术，诊断准确性高，可为非甲状腺肿块患者提供高敏感性诊断且假阳性诊断率低。
