Hoffman W W, Korst J J, Niblack J F, Cronin T H
Antimicrob Agents Chemother. 1973 Apr;3(4):498-502. doi: 10.1128/AAC.3.4.498.
CP-20,961, N,N-dioctadecyl-N', N'-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. Parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and Semliki Forest viruses and effectively suppressed pox formation by vaccinia infection. Maximal antiviral effects were observed when CP-20,961 was administered 6 to 12 h before infection. An interferon detected in plasma 12 to 20 h after the drug was given appeared to mediate these effects. Comparison of the minimal effective and lethal doses in mice established a therapeutic index of 300.
CP - 20961，即N，N - 二辛基 - N'，N' - 双（2 - 羟乙基）丙二胺，是一种对小鼠急性毒性较低的抗病毒药物。经肠胃外注射该化合物可保护小鼠免受脑心肌炎病毒和Semliki森林病毒的致死性感染，并有效抑制痘苗感染引起的痘疱形成。在感染前6至12小时给予CP - 20961时观察到最大抗病毒效果。给药后12至20小时在血浆中检测到的一种干扰素似乎介导了这些作用。通过比较小鼠的最小有效剂量和致死剂量确定治疗指数为300。
