N,N-二辛基-N',N'-双(2-羟乙基)丙二胺：小鼠体内的抗病毒活性及干扰素刺激作用
N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl) propanediamine: antiviral activity and interferon stimulation in mice.
作者信息
Hoffman W W, Korst J J, Niblack J F, Cronin T H
出版信息
Antimicrob Agents Chemother. 1973 Apr;3(4):498-502. doi: 10.1128/AAC.3.4.498.
Abstract
CP-20,961, N,N-dioctadecyl-N', N'-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. Parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and Semliki Forest viruses and effectively suppressed pox formation by vaccinia infection. Maximal antiviral effects were observed when CP-20,961 was administered 6 to 12 h before infection. An interferon detected in plasma 12 to 20 h after the drug was given appeared to mediate these effects. Comparison of the minimal effective and lethal doses in mice established a therapeutic index of 300.
摘要
CP - 20961，即N，N - 二辛基 - N'，N' - 双（2 - 羟乙基）丙二胺，是一种对小鼠急性毒性较低的抗病毒药物。经肠胃外注射该化合物可保护小鼠免受脑心肌炎病毒和Semliki森林病毒的致死性感染，并有效抑制痘苗感染引起的痘疱形成。在感染前6至12小时给予CP - 20961时观察到最大抗病毒效果。给药后12至20小时在血浆中检测到的一种干扰素似乎介导了这些作用。通过比较小鼠的最小有效剂量和致死剂量确定治疗指数为300。
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本文引用的文献
1
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Science. 1965 Jul 16;149(3681):310-1.
2
INTESTINAL ABSORPTION OF FATS.脂肪的肠道吸收
J Lipid Res. 1964 Oct;5:495-521.
3
Rabbit macrophage interferons. II. Some physicochemical properties and estimations of molecular weights.兔巨噬细胞干扰素。II. 一些物理化学性质及分子量测定
J Exp Med. 1967 Apr 1;125(4):579-93. doi: 10.1084/jem.125.4.579.
4
Induction of circulating interferon by synthetic anionic polymers of known composition.已知成分的合成阴离子聚合物诱导循环干扰素的产生。
Nature. 1967 Apr 22;214(5086):416-7. doi: 10.1038/214416a0.
5
Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice.通过抑制痘苗病毒感染小鼠的尾部损伤来评估抗病毒化合物。
Antimicrob Agents Chemother (Bethesda). 1966;6:536-9.
6
Influence of inhibitors of protein synthesis on interferon formation in mice.蛋白质合成抑制剂对小鼠体内干扰素形成的影响。
Virology. 1965 Dec;27(4):541-50. doi: 10.1016/0042-6822(65)90179-0.
7
Toxic properties of a synthetic double-stranded RNA. Endotoxin-like properties of poly I. poly C, an interferon stimulator.一种合成双链RNA的毒性特性。聚肌苷酸-聚胞苷酸（一种干扰素刺激剂）的类内毒素特性。
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8
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