奎纳克林和阿克拉尼尔的抗病毒活性及对干扰素样物质的诱导作用
Antiviral activity and induction of interferon-like substance by quinacrine and acranil.
作者信息
Gláz E T, Szolgay E, Stöger I, Tálas M
出版信息
Antimicrob Agents Chemother. 1973 May;3(5):537-41. doi: 10.1128/AAC.3.5.537.
Abstract
Several drugs with certain structural similarities (tricyclic ring system with dialkylaminoalkyl side chains) to tilorone, a potent interferon inducer, were screened for antiviral activity in vivo. Two acridine drugs, Acranil and quinacrine, were found to be effective, the former being almost as protective as tilorone and the latter less so. Both agents induced an interferon-like substance which could be detected in the serum of treated mice. The concentration of the inhibitory factor in the serum was highest after exposure to tilorone, followed in turn by Acranil and quinacrine, based on the administration of equal weights of drugs. Both tilorone and Acranil induced lower levels of circulating interferon-like substance in Balb/c mice than in other strains of mice. The serum factor induced by Acranil was shown to be stable at pH 2.
摘要
筛选了几种与强效干扰素诱导剂泰洛龙具有某些结构相似性（带有二烷基氨基烷基侧链的三环系统）的药物，以检测其体内抗病毒活性。发现两种吖啶类药物，即阿克拉尼和奎纳克林有效，前者的保护作用几乎与泰洛龙相同，后者则稍逊一筹。两种药物均诱导出一种类似干扰素的物质，可在经治疗小鼠的血清中检测到。基于给予等重量的药物，血清中抑制因子的浓度在接触泰洛龙后最高，其次依次是阿克拉尼和奎纳克林。与其他品系的小鼠相比，泰洛龙和阿克拉尼在Balb/c小鼠中诱导的循环中类似干扰素物质的水平较低。阿克拉尼诱导的血清因子在pH 2时显示稳定。
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