类风湿性关节炎滑液中抗胶原蛋白抗体及胶原蛋白-抗胶原蛋白免疫复合物的检测
Demonstration of antibodies to collagen and of collagen-anticollagen immune complexes in rheumatoid arthritis synovial fluids.
作者信息
Menzel J, Steffen C, Kolarz G, Eberal G, Frank O, Thumb N
出版信息
Ann Rheum Dis. 1975 Oct;35(5):446-50. doi: 10.1136/ard.35.5.446.
Abstract
Twenty-nine synovial fluids from patients with rheumatoid arthritis (RA) and 10 synovial fluids from patients with other joint diseases were investigated with regard to the presence of antibodies to denatured human collagen and of collagen-anticollagen immune complexes. 12 of the 29 RA synovial fluids showed anticollagen titres from 1:16 to 1:512 in passive haemagglutination. Only one patient in the group with no arthritis had a significant anticollagen titre of 1:32. Digestion of the synovial fluids with bacterial collagenase resulted in an anticollagen titre increase from two to four dilution steps in 9 of the RA fluids, while 6 previously negative RA synovial fluids showed anticollagen titres from 1:32 to 1:28 after digestion with collagenase. These results indicate the existence of collagen-anticollagen immune complexes in 15 of the 29 RA synovial fluids investigated.
摘要
对29份类风湿性关节炎（RA）患者的滑液和10份其他关节疾病患者的滑液进行了研究，以检测其中是否存在抗变性人胶原蛋白抗体和胶原蛋白 - 抗胶原蛋白免疫复合物。29份RA滑液中的12份在被动血凝试验中显示抗胶原蛋白滴度为1:16至1:512。在无关节炎的组中只有一名患者具有显著的1:32抗胶原蛋白滴度。用细菌胶原酶消化滑液后，9份RA滑液的抗胶原蛋白滴度增加了两到四个稀释度，而6份先前为阴性的RA滑液在用胶原酶消化后显示抗胶原蛋白滴度为1:32至1:28。这些结果表明，在所研究的29份RA滑液中，有15份存在胶原蛋白 - 抗胶原蛋白免疫复合物。
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