Addy M, Wade W, Goodfield S
University of Wales College of Medicine, Cardiff, South Wales.
Clin Prev Dent. 1991 Jan;13(1):13-7.
Dietary staining studies have proved useful determinants of chlorhixidine activity in mouthrinse products, and results correlate with plaque inhibitory effects. This investigation compared the staining and antimicrobial action in vitro of two known and similarly effective, commercially available chlorhexidine mouthrinses with a reformulated 0.1% chlordexidine preparation. After adjustment for original concentration the 0.2%, 0.12% and reformulated 0.1% products had essentially similar, minimum inhibitory-dilution values against standard test organisms. The 0.1% preparation was more effective against Capnocytophaga ochracea, suggesting additional antimicrobial activity derived from an ingredient other than chlorhexidine. The staining in vitro of tooth and acrylic specimens was equivalent with the 0.2% and 0.12% products. By comparison with equivalent concentrations of the diluted 0.2% preparation, the 0.1% formulation produced less staining, particularly when diluted. The data suggest that the 0.1% formulation, when used in diluted form as recommended by the manufacturer, may have slightly reduced plaque-inhibitory effects by comparison to the 0.2% or 0.12% products. However, the results raise the question whether chlorhexidine solutions could be formulated to reduce side effects, in particular, tooth staining at the expense of some loss of antiplaque activity.
饮食染色研究已证明是漱口水产品中洗必泰活性的有用决定因素，且结果与菌斑抑制作用相关。本研究比较了两种已知且效果相似的市售洗必泰漱口水与一种重新配方的0.1%洗必泰制剂在体外的染色和抗菌作用。在对原始浓度进行调整后，0.2%、0.12%和重新配方的0.1%产品对标准测试微生物的最低抑菌稀释值基本相似。0.1%的制剂对赭色纤毛菌更有效，表明除洗必泰外的其他成分具有额外的抗菌活性。0.2%和0.12%产品对牙齿和丙烯酸标本的体外染色效果相当。与稀释后的0.2%制剂的等效浓度相比，0.1%的配方染色较少，尤其是在稀释时。数据表明，按照制造商的建议以稀释形式使用时，0.1%的配方与0.2%或0.12%的产品相比，可能会使菌斑抑制作用略有降低。然而，这些结果提出了一个问题，即洗必泰溶液是否可以在以牺牲一定的抗牙菌斑活性为代价的情况下进行配方调整以减少副作用，特别是牙齿染色。
