来自象牙海岸和尼日利亚的人类及猿猴血清中的猴痘特异性抗体。
Monkeypox-specific antibodies in human and simian sera from the Ivory Coast and Nigeria.
作者信息
Gispen R, Brand-Saathof B B, Hekker A C
出版信息
Bull World Health Organ. 1976;53(4):355-60.
A test for monkeypox-specific antibodies is described. Monkeypox immune sera can be made type-specific by immunoabsorption with heterotypic poxvirus extracts. Monkeypox-specific antibodies were demonstrated in sera from 9 cynomolgus monkeys (Macaca fascicularis) that had previously been experimentally infected with monkeypox. Monkeypox-specific antibodies were found in 3 wild-caught African monkeys (Cercopithecus spp.) and in 3 human sera collected from Africans in the Ivory Coast and Nigeria 3(1/2)-4 years after they had suffered a pox-like infection. Monkeypox had been recognized in one of the patients by virus isolation, and had been suspected in the others for epidemiological reasons. Vaccinia-specific antibodies were found in 4 human sera collected 6 weeks after smallpox vaccination.The serological results provide the first laboratory evidence of a monkeypox reservoir in wild monkeys.
本文描述了一种针对猴痘特异性抗体的检测方法。猴痘免疫血清可通过用异型痘病毒提取物进行免疫吸附而实现型特异性。在先前经实验感染猴痘的9只食蟹猴（猕猴属）的血清中检测到了猴痘特异性抗体。在3只野生捕获的非洲猴（猕猴属）以及从象牙海岸和尼日利亚的非洲人身上采集的3份人血清中发现了猴痘特异性抗体，这些非洲人在患痘样感染3年半至4年后采集了血清。其中一名患者通过病毒分离确诊为猴痘，其他患者因流行病学原因被怀疑感染猴痘。在天花疫苗接种6周后采集的4份人血清中发现了牛痘特异性抗体。这些血清学结果提供了野生猴中存在猴痘储存宿主的首个实验室证据。
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