Byers David K, Decker Catherine F
Department of Internal Medicine, National Naval Medical Center, Bethesda, Maryland, USA.
AIDS Read. 2008 Jun;18(6):313-7.
Symptomatic primary HIV infection occurs in an estimated 50% to 90% of patients. A constellation of symptoms that most closely resembles those of acute infectious mononucleosis characterizes the syndrome. On rare occasions, opportunistic infections present simultaneously with primary HIV infection. We describe a patient who presented with an episode of severe Pneumocystis jiroveci pneumonia during what appeared to be a prolonged primary HIV infection. Serological testing demonstrated the progressive development of reactive bands on serial Western blot determinations. This case highlights how primary HIV infection can produce profound immunosuppression through CD4 lymphocytopenia predisposing patients to opportunistic infection.
估计有50%至90%的患者会出现有症状的原发性HIV感染。该综合征的特征是一组与急性传染性单核细胞增多症极为相似的症状。在极少数情况下，机会性感染会与原发性HIV感染同时出现。我们描述了一名患者，在看似是长期原发性HIV感染期间，出现了一次严重的耶氏肺孢子菌肺炎发作。血清学检测显示，在连续的蛋白质印迹测定中反应带呈进行性发展。该病例突出了原发性HIV感染如何通过CD4淋巴细胞减少导致严重免疫抑制，使患者易患机会性感染。
