Aguiar Aderbal S, Speck Ana E, Prediger Rui D S, Kapczinski Flávio, Pinho Ricardo A
Laboratório de Fisiologia e Bioquímica do Exercício, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciuma, SC 88806-000, Brazil.
J Neural Transm (Vienna). 2008 Sep;115(9):1251-5. doi: 10.1007/s00702-008-0071-2. Epub 2008 Jul 16.
This study examined the effects of downhill treadmill exercise on brain-derived neurotrophic factor (BDNF) protein on the hippocampus and striatum of mice. Twenty-four adult mice were assigned to three groups: non-runners control, level or downhill (16 degrees decline) running exercise. The exercise schedule consisted of progressive treadmill running for 5 days week(-1) over 8 weeks. Blood lactate levels classified exercise intensity as moderate to high. Both training types increased citrate synthase activity of the soleus muscle when compared to untrained controls. While level running increased BDNF levels selectively in the hippocampus (68.5%), the eccentric running resulted in a pronounced BDNF increase in both the hippocampus (137.0%) and the striatum (49.9%). Further studies will specify whether the observed alterations in BDNF are due to downhill-induced upregulation or complex learning-induced mechanisms that influence BDNF levels in these brain regions.
本研究考察了下坡跑步机运动对小鼠海马体和纹状体中脑源性神经营养因子（BDNF）蛋白的影响。将24只成年小鼠分为三组：非跑步对照组、水平跑步组或下坡（16度倾斜）跑步运动组。运动计划包括在8周内每周进行5天的递增式跑步机跑步。血乳酸水平将运动强度分类为中度至高。与未训练的对照组相比，两种训练类型均增加了比目鱼肌的柠檬酸合酶活性。虽然水平跑步选择性地增加了海马体中的BDNF水平（68.5%），但离心跑步导致海马体（137.0%）和纹状体（49.9%）中的BDNF显著增加。进一步的研究将明确观察到的BDNF变化是由于下坡诱导的上调还是影响这些脑区BDNF水平的复杂学习诱导机制。
