Malcolm G, Ellwood D, Devonald K, Beilby R, Henderson-Smart D
Department of Perinatal Medicine, King George V Hospital for Mothers and Babies, Camperdown, NSW, Australia.
Arch Dis Child. 1991 Jul;66(7 Spec No):805-7. doi: 10.1136/adc.66.7_spec_no.805.
Absent or reversed end diastolic flow (AREDF) velocities in the umbilical artery were identified in 25 high risk pregnancies. In six pregnancies the fetus was abnormal and all but one of these ended in perinatal death. Of the 19 morphologically normal fetuses, three died in utero and there were four neonatal or infant deaths. The mortality rate was 48% for all pregnancies and 37% for those with morphologically normal fetuses. There was a highly significant increased risk for the development of necrotising enterocolitis in these morphologically normal fetuses with AREDF (53%) compared with controls (6%) who did have umbilical artery end diastolic flow velocities in fetal life. There were no significant differences between the matched pairs for parameters of neonatal outcome chosen to reflect neonatal morbidity. These findings demonstrate the close association between AREDF and necrotising enterocolitis that appears to be independent of other variables such as degree of growth retardation, prematurity, and perinatal asphyxia.
在25例高危妊娠中发现脐动脉舒张末期血流速度缺失或反向（AREDF）。在6例妊娠中，胎儿异常，其中除1例之外其余均以围产期死亡告终。在19例形态正常的胎儿中，3例死于宫内，有4例新生儿或婴儿死亡。所有妊娠的死亡率为48%，形态正常胎儿的妊娠死亡率为37%。与胎儿期有脐动脉舒张末期血流速度的对照组（6%）相比，这些有AREDF的形态正常胎儿发生坏死性小肠结肠炎的风险显著增加（53%）。在为反映新生儿发病率而选择的新生儿结局参数方面，匹配对之间没有显著差异。这些发现表明，AREDF与坏死性小肠结肠炎之间存在密切关联，这似乎独立于其他变量，如生长迟缓程度、早产和围产期窒息。
