Akada Shinji, Takeda Shinhiro, Yoshida Yuko, Nakazato Keiko, Mori Masaki, Hongo Takashi, Tanaka Keiji, Sakamoto Atsuhiro
Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Anesth Analg. 2008 Jul;107(1):167-70. doi: 10.1213/ane.0b013e3181732dc2.
Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.
This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.
Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.
This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.
躁动与无创通气（NIV）失败相关。我们研究了右美托咪定对NIV患者的影响。
这是一项在重症监护病房进行的前瞻性临床研究。对10例因躁动而难以进行NIV的患者输注右美托咪定。
Ramsay评分和Richmond躁动-镇静量表评分分别维持在2.94±0.94和-1.23±1.30。所有患者均成功撤离NIV，呼吸状态未恶化。
本研究表明，右美托咪定对NIV患者是一种有效的镇静药物。
