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1
When HDL gets fat..当高密度脂蛋白变“胖”时……
Circ Res. 2008 Jul 18;103(2):131-2. doi: 10.1161/CIRCRESAHA.108.180638.
2
Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia.残余高密度脂蛋白颗粒的细胞摄取增强：胰岛素抵抗和高甘油三酯血症中高密度脂蛋白降低的一种机制。
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3
FoxO transcription factors are required for hepatic HDL cholesterol clearance.FoxO 转录因子对于肝脏清除 HDL 胆固醇是必需的。
J Clin Invest. 2018 Apr 2;128(4):1615-1626. doi: 10.1172/JCI94230. Epub 2018 Mar 19.
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Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor.胆固醇酯转运蛋白（CETP）的表达增强了高密度脂蛋白胆固醇酯向肝脏的转运，这一过程独立于清道夫受体BI、低密度脂蛋白受体相关蛋白，可能还独立于低密度脂蛋白受体。
Biochim Biophys Acta. 2006 Dec;1761(12):1482-8. doi: 10.1016/j.bbalip.2006.09.008. Epub 2006 Sep 20.
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LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models.载脂蛋白 B100 降解产物通过与载脂蛋白 A-I 形成复合物来调节高密度脂蛋白的代谢
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Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I.胆固醇酯转运蛋白（CETP）在体内以及CETP和肝脂酶在体外对高密度脂蛋白（HDL）进行重塑，导致表达清道夫受体B-I的细胞对HDL胆固醇酯（CE）的摄取增加。
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Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency.在清道夫受体 B 类 I 型（SR-BI）敲除小鼠中通过胆固醇酯转移蛋白表达恢复高密度脂蛋白水平不能使与 SR-BI 缺乏相关的病理正常化。
Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1439-45. doi: 10.1161/ATVBAHA.110.205153. Epub 2010 Apr 29.
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Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity.胰岛素抵抗、高甘油三酯血症状态下高密度脂蛋白降低的机制：高密度脂蛋白甘油三酯富集与肝脂酶活性升高的联合作用
Clin Biochem. 2003 Sep;36(6):421-9. doi: 10.1016/s0009-9120(03)00078-x.
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In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis.脂肪组织中SR-BI在肥胖和胆固醇稳态的营养及激素调节中作用的体内证据。
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1340-5. doi: 10.1161/ATVBAHA.106.136382. Epub 2007 Mar 15.
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Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus.脂肪酶、卵磷脂胆固醇酰基转移酶和胆固醇酯转移蛋白在胰岛素抵抗和2型糖尿病异常高密度脂蛋白代谢中的作用
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Different profiles of lipoprotein particles associate various degrees of cardiac involvement in adolescents with morbid obesity.不同的脂蛋白颗粒谱与病态肥胖青少年不同程度的心脏受累相关。
Front Pediatr. 2022 Nov 22;10:887771. doi: 10.3389/fped.2022.887771. eCollection 2022.
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New insights into the mechanism of low high-density lipoprotein cholesterol in obesity.肥胖患者低高密度脂蛋白胆固醇机制的新见解。
Lipids Health Dis. 2011 Oct 12;10:176. doi: 10.1186/1476-511X-10-176.
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Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey.冠心病的一级预防：新数据整合、观点演变、目标修订以及瑞舒伐他汀在管理中的作用。一项全面综述。
Drug Des Devel Ther. 2011;5:325-80. doi: 10.2147/DDDT.S14934. Epub 2011 Jun 13.
5
The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver.eSS 大鼠，一种葡萄糖和脂代谢紊乱及脂肪肝的非肥胖模型。
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本文引用的文献

1
Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia.残余高密度脂蛋白颗粒的细胞摄取增强：胰岛素抵抗和高甘油三酯血症中高密度脂蛋白降低的一种机制。
Circ Res. 2008 Jul 18;103(2):159-66. doi: 10.1161/CIRCRESAHA.108.178756. Epub 2008 Jun 12.
2
Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches.除高密度脂蛋白胆固醇水平外，评估新型治疗方法对高密度脂蛋白功能的影响。
J Am Coll Cardiol. 2008 Jun 10;51(23):2199-211. doi: 10.1016/j.jacc.2008.03.016.
3
Endothelial lipase is increased in vivo by inflammation in humans.在人体内，炎症会使内皮脂肪酶在体内水平升高。
Circulation. 2008 Feb 5;117(5):678-85. doi: 10.1161/CIRCULATIONAHA.107.707349. Epub 2008 Jan 22.
4
Glycosylation of endothelial lipase at asparagine-116 reduces activity and the hydrolysis of native lipoproteins in vitro and in vivo.
J Lipid Res. 2007 May;48(5):1132-9. doi: 10.1194/jlr.M600535-JLR200. Epub 2007 Feb 24.
5
Molecular regulation of HDL metabolism and function: implications for novel therapies.高密度脂蛋白代谢与功能的分子调控：对新型疗法的启示
J Clin Invest. 2006 Dec;116(12):3090-100. doi: 10.1172/JCI30163.
6
High-density lipoprotein (HDL) transport in the metabolic syndrome: application of a new model for HDL particle kinetics.代谢综合征中的高密度脂蛋白（HDL）转运：HDL颗粒动力学新模型的应用
J Clin Endocrinol Metab. 2006 Mar;91(3):973-9. doi: 10.1210/jc.2005-1895. Epub 2005 Dec 20.
7
Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis.代谢综合征患者的内皮脂肪酶浓度升高，且与冠状动脉粥样硬化相关。
PLoS Med. 2006 Feb;3(2):e22. doi: 10.1371/journal.pmed.0030022. Epub 2005 Dec 20.
8
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia.由高血糖驱动的极低密度脂蛋白1（VLDL1）过度产生是糖尿病血脂异常的一个主要特征。
Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1697-703. doi: 10.1161/01.ATV.0000172689.53992.25. Epub 2005 Jun 9.
9
The role of endothelial lipase in high-density lipoprotein metabolism.内皮脂肪酶在高密度脂蛋白代谢中的作用。
Curr Opin Cardiol. 2004 Jul;19(4):392-5. doi: 10.1097/01.hco.0000130161.89169.02.
10
Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein A-I.人肝脂酶在兔模型中的表达优先增强富含甘油三酯的脂蛋白相对于天然高密度脂蛋白载脂蛋白A-I的清除。
Circulation. 2003 Jun 24;107(24):3066-72. doi: 10.1161/01.CIR.0000070947.64595.47. Epub 2003 Jun 9.

When HDL gets fat..

作者信息

Brown Robert J, Rader Daniel J

出版信息

Circ Res. 2008 Jul 18;103(2):131-2. doi: 10.1161/CIRCRESAHA.108.180638.

DOI:10.1161/CIRCRESAHA.108.180638
PMID:18635830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2803051/
Abstract
摘要