Torres-Sanchez Luisa, Galvan-Portillo Marcia, Wolff Mary S, Lopez-Carrillo Lizbeth
Instituto Nacional de Salud Pública, Av. Universidad No. 655, Col. Sta. María Ahuacatitlán, CP 62508, Cuernavaca, Morelos, Mexico.
Public Health Nutr. 2009 Jun;12(6):825-31. doi: 10.1017/S136898000800325X. Epub 2008 Jul 23.
To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women.
We conducted hospital-based case-control study.
Mexico City between 1994 and 1996.
A total of 141 histologically confirmed BC cases were age-matched (+/-3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ.
Among postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR = 0.21, 95 % CI 0.07, 0.60, P for trend = 0.004 and OR = 0.29, 95 % CI 0.10, 0.82, P for trend = 0.025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR = 0.32, 95 % CI 0.10, 0.99, P for trend = 0.051 and OR = 0.19, 95 % CI 0.06, 0.62, P for trend = 0.006, respectively).
Our results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.
评估墨西哥女性特定植物化学物质的摄入量与乳腺癌（BC）风险之间的关系。
我们开展了一项基于医院的病例对照研究。
1994年至1996年期间的墨西哥城。
共有141例经组织学确诊的BC病例，与数量相等的医院对照进行年龄匹配（±3岁）。通过直接访谈获取每位女性的生殖史。通过经过验证的食物频率问卷（FFQ）获取黄酮醇、黄酮、黄烷-3-醇、肉桂酸、落叶松脂醇、松脂醇、开环异落叶松脂醇、罗汉松脂醇和香豆雌酚的饮食摄入量。
在绝经后女性中，高黄酮醇和黄酮饮食摄入量与BC风险显著降低相关（高摄入量组与低摄入量组三分位数相比：OR = 0.21，95%CI 0.07，0.60，趋势P值 = 0.004；OR = 0.29，95%CI 0.10，0.82，趋势P值 = 0.025）；木脂素（落叶松脂醇和松脂醇）的摄入也显示出类似效果，但仅在绝经前女性中（高摄入量组与低摄入量组三分位数相比：OR = 0.32，95%CI 0.10，0.99，趋势P值 = 0.051；OR = 0.19，95%CI 0.06，0.62，趋势P值 = 0.006）。
我们的结果支持特定饮食植物化学物质根据绝经状态对BC风险具有保护作用，且独立于其他生殖因素。
