使用胃食管反流病症状频率量表对有喉咽反流症状患者的上腹部症状进行评估。
Evaluation of upper abdominal symptoms using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease in patients with laryngopharyngeal reflux symptoms.
作者信息
Oridate Nobuhiko, Takeda Hiroshi, Mesuda Yasushi, Nishizawa Noriko, Furuta Yasushi, Asaka Masahiro, Fukuda Satoshi
机构信息
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
出版信息
J Gastroenterol. 2008;43(7):519-23. doi: 10.1007/s00535-008-2189-2. Epub 2008 Jul 23.
BACKGROUND
The purpose of the study was to evaluate upper abdominal symptoms in laryngopharyngeal reflux (LPR) patients and changes in both upper abdominal and LPR symptoms before and after acid-suppression therapy.
METHODS
In 100 patients with LPR symptoms, upper abdominal and LPR symptoms were evaluated by using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and the LPR symptom scoring system, respectively. In the 52 assessable patients, changes in these symptoms before and after acid-suppression therapy were evaluated.
RESULTS
Upper abdominal symptoms were reported by 96/100 LPR patients: 89 responded positively to at least one of the questions about acid reflux-related symptoms and 89 to at least one of those about dysmotility-like symptoms. There was poor correlation between positive rates to FSSG upper abdominal symptom questions and the frequency of reported laryngopharyngeal symptoms. There were significant reductions in the frequency of acid reflux-related symptoms, dysmotility-like symptoms, and laryngopharyngeal symptoms after acidsuppression therapy. The LPR symptom score decreased to less than half the pretreatment score in 25 subjects (therapeutic response group). The pretreatment frequency of dysmotility-like symptoms seemed to be higher in the nonresponse group than in the response group, although the difference was not significant. There was no significant difference between the two groups in the pretreatment frequency of acid reflux-related symptoms.
CONCLUSIONS
The majority of these Japanese LPR patients experienced some form of upper abdominal symptoms. The frequency of dysmotility-like symptoms was similar to that of acid reflux-related symptoms. The pretreatment frequency of dysmotility-like symptoms, but not of acid reflux-related symptoms, might be a predictor of patient response to acid-suppression therapy.
背景
本研究旨在评估喉咽反流（LPR）患者的上腹部症状，以及抑酸治疗前后上腹部症状和LPR症状的变化。
方法
对100例有LPR症状的患者，分别使用胃食管反流病症状频率量表（FSSG）和LPR症状评分系统评估上腹部症状和LPR症状。在52例可评估的患者中，评估抑酸治疗前后这些症状的变化。
结果
100例LPR患者中有96例报告有上腹部症状：89例对至少一个与酸反流相关症状的问题回答为阳性，89例对至少一个与运动障碍样症状的问题回答为阳性。FSSG上腹部症状问题的阳性率与报告的喉咽症状频率之间相关性较差。抑酸治疗后，酸反流相关症状、运动障碍样症状和喉咽症状的频率显著降低。25例患者（治疗反应组）的LPR症状评分降至治疗前评分的一半以下。非反应组运动障碍样症状的治疗前频率似乎高于反应组，尽管差异不显著。两组酸反流相关症状的治疗前频率无显著差异。
结论
这些日本LPR患者中的大多数经历了某种形式的上腹部症状。运动障碍样症状的频率与酸反流相关症状的频率相似。运动障碍样症状而非酸反流相关症状的治疗前频率可能是患者对抑酸治疗反应的预测指标。
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