Francis Brian A, Varma Rohit, Chopra Vikas, Lai Mei-Ying, Shtir Corina, Azen Stanley P
Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Am J Ophthalmol. 2008 Nov;146(5):741-6. doi: 10.1016/j.ajo.2008.05.048. Epub 2008 Jul 30.
To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship.
Population-based cross-sectional study.
The study cohort consisted of 5,970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal, or thick.
Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCTs at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP.
These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population based assessment of glaucoma prevalence; CCT, however, is an important independent risk factor for the prevalence of OAG.
研究开角型青光眼（OAG）患病率与眼压（IOP）之间的关系，以及中央角膜厚度（CCT）对这种关系的影响。
基于人群的横断面研究。
研究队列包括来自洛杉矶拉丁裔眼研究（LALES）的5970名参与者，这些参与者无青光眼治疗史且有完整的眼科检查数据。将CCT分为薄、正常或厚的人群，对比OAG患病率与IOP之间的关系。
OAG患病率与IOP呈指数关系。按CCT分层时，在所有眼压水平下，CCT薄的人群OAG患病率显著高于CCT正常或厚的人群。针对CCT对每个眼压值进行单独校正，对OAG患病率与IOP之间的关系没有显著影响。
这些发现表明，在基于人群的青光眼患病率评估中，无需通过校正算法来校正CCT对眼压的影响；然而，CCT是OAG患病率的一个重要独立危险因素。
