Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Ophthalmology. 2010 Sep;117(9):1713-9. doi: 10.1016/j.ophtha.2010.01.035. Epub 2010 Jun 8.
To examine the associations among myopic refractive error (MRE), corneal power (CP), axial length (AL), and the prevalence of open-angle glaucoma (OAG) in an adult Latino population.
Population-based, cross-sectional epidemiologic study.
A total of 5927 Latinos aged 40 years and older in the Los Angeles Latino Eye Study (LALES).
Myopic refractive error was defined as a non-cycloplegic sphero-cylindrical refractive error of < or =-1 diopter (D). Axial length was measured by A-scan ultrasound. Corneal power was measured using a Humphrey auto-refractor. Open-angle glaucoma was diagnosed by a combination of optic nerve and visual field changes. Pseudophakic and aphakic eyes were excluded from the analysis. The associations among MRE, AL, CP, and the prevalence of OAG were calculated using a logistic regression model, adjusting for age, gender, intraocular pressure, central corneal thickness, diabetes mellitus, family history of glaucoma, and lens nuclear opacification (NO).
Odds ratios (OR) for the prevalence of OAG.
After adjusting for covariates, persons with greater MRE (OR 1.82; confidence interval [CI], 1.20-2.77; P = 0.005), longer AL (OR 1.25; CI, 1.03-1.50; P = 0.02), and flatter corneas (OR 1.21; CI, 1.08-1.35; P = 0.0007) were associated with a higher prevalence of OAG when compared with those with emmetropic refractive error, shorter AL, and steeper corneas.
Persons with an MRE, flatter corneas, and longer ALs should be considered to be at higher risk of having OAG.
在拉丁裔成年人中，研究近视屈光不正（MRE）、角膜曲率（CP）、眼轴（AL）与开角型青光眼（OAG）之间的相关性。
基于人群的横断面流行病学研究。
洛杉矶拉丁裔眼研究（LALES）中年龄在 40 岁及以上的共 5927 名拉丁裔。
近视屈光不正定义为非睫状肌麻痹性球镜-柱镜屈光不正<或=-1 屈光度（D）。眼轴用 A 型超声测量。角膜曲率用 Humphrey 自动折射计测量。开角型青光眼的诊断是根据视神经和视野改变相结合的。将白内障和无晶状体眼从分析中排除。使用逻辑回归模型，调整年龄、性别、眼压、中央角膜厚度、糖尿病、青光眼家族史和晶状体核混浊（NO）后，计算 MRE、AL、CP 与 OAG 之间的关联。
OAG 患病率的比值比（OR）。
调整了协变量后，MRE 较大的患者（OR 1.82；95%置信区间[CI]，1.20-2.77；P=0.005）、眼轴较长的患者（OR 1.25；CI，1.03-1.50；P=0.02）和角膜较平坦的患者（OR 1.21；CI，1.08-1.35；P=0.0007）与正视屈光不正、较短的 AL 和较陡的角膜相比，患 OAG 的概率更高。
MRE、角膜平坦和眼轴较长的患者应被认为有更高的 OAG 风险。
