Thirkill C E, Roth A M, Takemoto D J, Tyler N K, Keltner J L
Department of Ophthalmology, University of California, Davis.
Am J Ophthalmol. 1991 Aug 15;112(2):132-7. doi: 10.1016/s0002-9394(14)76691-7.
Antibody reactions with recognized retinopathy-inducing retinal antigens may be interpreted to reflect ongoing autoimmune events responsible for some forms of vision loss. We sought evidence of secondary and superimposed retinal hypersensitivity indicated by such antibody reactivity in a random group of patients with retinitis pigmentosa. We identified patterns of immunologic reactivity within members of a group of 52 patients with retinitis pigmentosa, which suggests some patients with retinitis pigmentosa may experience consequential superimposed retinal hypersensitivity. Identifying subgroups of patients with retinitis pigmentosa who exhibit indications of retinal hypersensitivity to known uveitopathogenic retinal proteins may permit the reduction of their rate of retinal degradation by immunomodulation.
与公认的可诱发视网膜病变的视网膜抗原发生的抗体反应，可能被解读为反映了导致某些形式视力丧失的正在进行的自身免疫事件。我们在一组随机选取的色素性视网膜炎患者中，寻找由这种抗体反应性所表明的继发性和叠加性视网膜超敏反应的证据。我们在一组52例色素性视网膜炎患者中确定了免疫反应模式，这表明一些色素性视网膜炎患者可能会经历继发性叠加性视网膜超敏反应。识别出对已知葡萄膜致病性视网膜蛋白表现出视网膜超敏反应迹象的色素性视网膜炎患者亚组，可能会通过免疫调节降低他们的视网膜退化速度。
