Kochel Tadeusz, Aguilar Patricia, Felices Vidal, Comach Guillermo, Cruz Cristopher, Alava Aracely, Vargas Jorge, Olson James, Blair Patrick
United States Naval Medical Research Center Detachment, Unit 3800, APO AA 34031, American Embassy, Lima, Peru.
Infect Genet Evol. 2008 Sep;8(5):682-8. doi: 10.1016/j.meegid.2008.06.008. Epub 2008 Jul 11.
A phylogenetic approach was used to identify genetic variants of DENV-3 subtype III that may have emerged during or after its expansion throughout South America. We sequenced the capsid, premembrane/membrane and envelope genes from 22 DENV-3 strains isolated from Venezuela, Bolivia, Ecuador and Peru between 2000 and 2005. Phylogenetic analysis showed that the isolates sequenced in this study formed three clades within subtype III: one with the isolates from Venezuela, one with the Bolivian isolates and one with the isolates from Ecuador and Peru.
采用系统发育方法来鉴定登革热病毒3型（DENV-3）III亚型在整个南美洲传播期间或之后可能出现的基因变异。我们对2000年至2005年间从委内瑞拉、玻利维亚、厄瓜多尔和秘鲁分离出的22株DENV-3病毒株的衣壳、前膜/膜和包膜基因进行了测序。系统发育分析表明，本研究中测序的分离株在III亚型内形成了三个分支：一个分支包含来自委内瑞拉的分离株，一个分支包含来自玻利维亚的分离株，另一个分支包含来自厄瓜多尔和秘鲁的分离株。
