β-内啡肽：对吗啡产生交叉耐受性和交叉身体依赖性。
beta-Endorphin: cross tolerance to and cross physical dependence on morphine.
作者信息
Tseng L F, Loh H H, Li C H
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4187-9. doi: 10.1073/pnas.73.11.4187.
Abstract
The effects of beta-endorphin on the antinociceptive responses and abrupt withdrawal jumping in morphine-dependent mice were studied. Mice were rendered morphine dependent by implantation of a morphine pellet (75 mg base) for 3 days. The analgesic response to beta-endorphin decreased after morphine pellet implantation, as evidenced by an eight-fold increase in the median antinociceptive dose of morphine was found. In small doses (0.09-0.17 mug per mouse), beta-endorphin suppressed abrupt withdrawal jumping. Met-enkephalin, even in high doses (200 mug per mouse), did not suppress abrupt withdrawal jumping.
摘要
研究了β-内啡肽对吗啡依赖小鼠抗伤害感受反应和突然戒断跳跃的影响。通过植入吗啡丸（75mg碱）3天使小鼠产生吗啡依赖。植入吗啡丸后，对β-内啡肽的镇痛反应降低，这通过吗啡的半数抗伤害感受剂量增加了八倍得到证明。小剂量（每只小鼠0.09 - 0.17μg）的β-内啡肽可抑制突然戒断跳跃。甲硫氨酸脑啡肽，即使是高剂量（每只小鼠200μg），也不能抑制突然戒断跳跃。
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