Giuliano Anna R, Lazcano-Ponce Eduardo, Villa Luisa L, Flores Roberto, Salmeron Jorge, Lee Ji-Hyun, Papenfuss Mary R, Abrahamsen Martha, Jolles Emily, Nielson Carrie M, Baggio Maria Luisa, Silva Roberto, Quiterio Manuel
H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC 2067D, Tampa, FL 33612, USA.
Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2036-43. doi: 10.1158/1055-9965.EPI-08-0151.
Male sexual behavior influences the rates of cervical dysplasia and invasive cervical cancer, as well as male human papillomavirus (HPV) infection and disease. Unfortunately, little is known regarding male HPV type distribution by age and across countries. In samples combined from the coronal sulcus, glans penis, shaft, and scrotum of 1,160 men from Brazil, Mexico, and the United States, overall HPV prevalence was 65.2%, with 12.0% oncogenic types only, 20.7% nononcogenic types only, 17.8% both oncogenic and nononcogenic, and 14.7% unclassified infections. Multiple HPV types were detected in 25.7% of study participants. HPV prevalence was higher in Brazil (72.3%) than in the United States (61.3%) and Mexico (61.9%). HPV16 (6.5%), HPV51 (5.3%), and HPV59 (5.3%) were the most commonly detected oncogenic infections, and HPV84 (7.7%), HPV62 (7.3%), and HPV6 (6.6%) were the most commonly detected nononcogenic infections. Overall HPV prevalence was not associated with age. However, significant associations with age were observed when specific categories of HPV, nononcogenic, and unclassified HPV infections were considered. Studies of HPV type distribution among a broad age range of men from multiple countries is needed to fill the information gap internationally with respect to our knowledge of HPV infection in men.
男性性行为会影响宫颈发育异常和浸润性宫颈癌的发病率，以及男性人乳头瘤病毒（HPV）感染和疾病。遗憾的是，关于按年龄和跨国的男性HPV类型分布情况，人们了解甚少。在来自巴西、墨西哥和美国的1160名男性冠状沟、阴茎头、阴茎体和阴囊的联合样本中，HPV总体感染率为65.2%，仅致癌型为12.0%，仅非致癌型为20.7%，致癌型和非致癌型均有的为17.8%，未分类感染为14.7%。25.7%的研究参与者检测到多种HPV类型。巴西的HPV感染率（72.3%）高于美国（61.3%）和墨西哥（61.9%）。HPV16（6.5%）、HPV51（5.3%）和HPV59（5.3%）是最常检测到的致癌感染类型，HPV84（7.7%）、HPV62（7.3%）和HPV6（6.6%）是最常检测到的非致癌感染类型。HPV总体感染率与年龄无关。然而，在考虑特定类别的HPV、非致癌型和未分类HPV感染时，观察到与年龄有显著关联。需要对来自多个国家的广泛年龄范围男性中的HPV类型分布进行研究，以填补国际上关于男性HPV感染知识方面的信息空白。
