Karabudak Ozlem, Ulusoy Rifat Eralp, Erikci Alev Akyol, Solmazgul Emrullah, Dogan Bilal, Harmanyeri Yavuz
Department of Dermatology, GATA Teaching Hospital, GATA Teaching Hospital, Istanbul, Turkey.
Acta Derm Venereol. 2008;88(4):337-40. doi: 10.2340/00015555-0456.
Hyperhomocysteinaemia is a well-known risk factor for cardiovascular disease and plays a role in atherothrombosis. Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased thrombosis. The aim of this study was to examine serum homocysteine levels and their relationships with inflammatory and atherothrombotic markers in psoriasis. Twenty patients with mild or moderate psoriasis and 20 age-matched healthy men were included in this study. Patients with acquired hyperhomocysteinaemia were excluded from both groups. The inflammation markers, mean platelet volume, C-reactive protein and ceruloplasmin levels, were significantly increased in the study group compared with the control group. In the study group there was decreased antithrombin III and total homocysteine levels, for haemostatic parameters. Folic acid levels, cardiovascular risk factors, endothelial inflammation markers and blood coagulation factors demonstrated significant correlations. Folic acid levels correlated inversely with homocysteine and positively with fibrinogen levels. In conclusion, increased homocysteine concentration and inflammation markers may play a role in the atherothrombotic state in psoriasis.
高同型半胱氨酸血症是心血管疾病的一个众所周知的危险因素，并且在动脉粥样硬化血栓形成中起作用。银屑病是一种常见的慢性复发性炎症性皮肤病，与血栓形成增加有关。本研究的目的是检测银屑病患者的血清同型半胱氨酸水平及其与炎症和动脉粥样硬化血栓形成标志物的关系。本研究纳入了20例轻度或中度银屑病患者和20例年龄匹配的健康男性。两组均排除获得性高同型半胱氨酸血症患者。与对照组相比，研究组的炎症标志物、平均血小板体积、C反应蛋白和铜蓝蛋白水平显著升高。在研究组中，抗凝血酶III和总同型半胱氨酸水平降低，为止血参数。叶酸水平、心血管危险因素、内皮炎症标志物和凝血因子显示出显著相关性。叶酸水平与同型半胱氨酸呈负相关，与纤维蛋白原水平呈正相关。总之，同型半胱氨酸浓度和炎症标志物的升高可能在银屑病的动脉粥样硬化血栓形成状态中起作用。
