Cakmak S K, Gül U, Kiliç C, Gönül M, Soylu S, Kiliç A
2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Ministry of Health, Ankara, Turkey.
J Eur Acad Dermatol Venereol. 2009 Mar;23(3):300-3. doi: 10.1111/j.1468-3083.2008.03024.x. Epub 2008 Dec 18.
Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported.
The aim of our study was to examine serum homocysteine, folic acid and vitamin B12 levels in psoriasis patients.
We performed a cross-sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age- and gender-matched controls. Serum levels of homocysteine, vitamin B12 and folic acid levels were measured in both groups.
Serum homocysteine, folic acid and vitamin B12 levels did not differ between patient and control groups. In psoriasis patients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group.
Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.
高同型半胱氨酸血症是动脉粥样硬化性心血管疾病、中风、外周动脉闭塞性疾病和静脉血栓形成的危险因素。已有报道称银屑病与心血管疾病之间存在关联。
我们研究的目的是检测银屑病患者的血清同型半胱氨酸、叶酸和维生素B12水平。
我们对70例连续性慢性斑块状银屑病门诊患者和70例年龄及性别匹配的对照者进行了一项横断面研究。两组均检测了血清同型半胱氨酸、维生素B12和叶酸水平。
患者组和对照组的血清同型半胱氨酸、叶酸和维生素B12水平无差异。在银屑病患者中，同型半胱氨酸水平与通过银屑病面积和严重程度指数测量的银屑病严重程度直接相关。患者组血清同型半胱氨酸水平与血清叶酸水平呈负相关。
患者组中同型半胱氨酸水平与银屑病面积和严重程度指数相关，这表明了疾病的严重程度。银屑病严重程度增加导致心血管死亡率升高也可能是由于同型半胱氨酸的作用。
