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雀麦花叶病毒衣壳的自组装:较短时间尺度实验的见解

Self-assembly of brome mosaic virus capsids: insights from shorter time-scale experiments.

作者信息

Chen Chao, Kao C Cheng, Dragnea Bogdan

机构信息

Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.

出版信息

J Phys Chem A. 2008 Oct 2;112(39):9405-12. doi: 10.1021/jp802498z. Epub 2008 Aug 28.

Abstract

An amended kinetic model for the self-assembly of empty capsids of brome mosaic virus is proposed. The model has been modified to account for a new feature in the assembly kinetics revealed by time-course light scattering experiments at higher temporal resolution than previously attempted. To be able to simulate the sharp takeoff from the initial lag phase to the growth phase in the kinetic curves, a monomer activation step was proposed.

摘要

提出了一种修正的雀麦花叶病毒空衣壳自组装动力学模型。该模型已被修改,以解释在比之前尝试的更高时间分辨率下通过时间进程光散射实验揭示的组装动力学中的一个新特征。为了能够模拟动力学曲线中从初始延迟阶段到生长阶段的急剧起飞,提出了一个单体激活步骤。

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