Zhu Jia-Jin, Shi Jia-Hui, Qian Wen-Bin, Cai Zhen-Zhen, Li Duo
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, PR China.
Lipids Health Dis. 2008 Aug 29;7:30. doi: 10.1186/1476-511X-7-30.
Cardiovascular disease (CVD) and colon cancer incidence are known to be closely related to dietary factors. This article evaluated effects of krill oil (KO) on serum lipids of hyperlipidemia rats and human colon cancer cells (SW480). Serum lipids of rats fed with high fat diet (HFD) and different doses of KO were measured by automatic analyzer. Effect of KO on viability of cells was determined by methyl thiazolyl tetrazolium (MTT) assay.
Except for higher dose group, body weights decreased significantly. Total cholesterol (TC), LDL-cholesterol (LDL-C) of all dose groups, Triglycerides (TG) of low and mid dose groups descended significantly, while there were no significant differences of HDL-cholesterol (HDL-C), compared with control group. Treatment of colon cancer cells with KO also resulted in time-dependent inhibition of cell growth.
Our findings indicated that the consumption of KO may provide benefits to control serum lipid levels in certain diseases and inhibit growth of colon cancer cells. Therefore, KO may be a good candidate for development as a functional food and nutraceutical.
已知心血管疾病（CVD）和结肠癌的发病率与饮食因素密切相关。本文评估了磷虾油（KO）对高脂血症大鼠血清脂质及人结肠癌细胞（SW480）的影响。采用自动分析仪测定高脂饮食（HFD）喂养大鼠及不同剂量KO的血清脂质。通过甲基噻唑基四氮唑（MTT）法测定KO对细胞活力的影响。
除高剂量组外，体重显著下降。与对照组相比，所有剂量组的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）以及低、中剂量组的甘油三酯（TG）均显著下降，而高密度脂蛋白胆固醇（HDL-C）无显著差异。用KO处理结肠癌细胞也导致细胞生长的时间依赖性抑制。
我们的研究结果表明，食用KO可能有助于控制某些疾病的血清脂质水平并抑制结肠癌细胞的生长。因此，KO可能是开发功能性食品和营养保健品的良好候选物。
