Santodomingo-Rubido Jacinto, Barrado-Navascués Eva, Rubido-Crespo María-José
EURO-OPTICA, Iglesia 9, 28220 Majadahonda, Madrid, Spain.
Ophthalmic Physiol Opt. 2008 Sep;28(5):497-501. doi: 10.1111/j.1475-1313.2008.00590.x.
Whereas there are numerous reported ocular side-effects from isotretinoin medication, we present the first case report of corneal steepening after systemic treatment with isotretinoin for seven and a half weeks. The case was associated with a significant drop in visual acuity which could not be explained from the refractive error change. All signs and symptoms were absent seven and a half weeks after the medication was withdrawn. The case indicates that eye care professionals need to be vigilant about the possibility of adverse ocular manifestations associated with the use of systemic medications.
尽管有大量关于异维甲酸药物眼部副作用的报道，但我们首次报告了一例在全身使用异维甲酸治疗七周半后角膜变陡的病例。该病例伴有视力显著下降，而屈光不正变化无法解释这一现象。停药七周半后，所有体征和症状均消失。该病例表明，眼科护理专业人员需要警惕与全身用药相关的眼部不良反应的可能性。
