Yang Yun-Liang, Cheng Ming-Fang, Chang Ya-Wen, Young Tzuu-Guang, Chi Hsin, Lee Sai Cheong, Cheung Bruno Man-Hon, Tseng Fan-Chen, Chen Tun-Chieh, Ho Yu-Huai, Shi Zhi-Yuan, Chan Chung-Huang Hubert, Lin Ju-Yu, Lo Hsiu-Jung
Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China.
J Negat Results Biomed. 2008 Dec 16;7:12. doi: 10.1186/1477-5751-7-12.
Nosocomial yeast infections have significantly increased during the past two decades in industrialized countries, including Taiwan. This has been associated with the emergence of resistance to fluconazole and other antifungal drugs. The medical records of 88 patients, colonized or infected with Candida species, from nine of the 22 hospitals that provided clinical isolates to the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program in 1999 were reviewed. A total of 35 patients contributed fluconazole resistant strains [minimum inhibitory concentrations (MICs) > or = 64 mg/l], while the remaining 53 patients contributed susceptible ones (MICs < or = 8 mg/l). Fluconazole resistance was more frequent among isolates of Candida tropicalis (46.5%) than either C. albicans (36.8%) or C. glabrata (30.8%). There was no significant difference in demographic characteristics or underlying diseases among patients contributing strains different in drug susceptibility.
在过去二十年中，包括台湾地区在内的工业化国家，医院内酵母菌感染显著增加。这与对氟康唑及其他抗真菌药物的耐药性出现有关。回顾了1999年向台湾酵母菌抗菌药物耐药性监测（TSARY）项目提供临床分离株的22家医院中9家医院的88例念珠菌属定植或感染患者的病历。共有35例患者提供了氟康唑耐药菌株[最低抑菌浓度（MIC）≥64mg/L]，其余53例患者提供了敏感菌株（MIC≤8mg/L）。热带念珠菌分离株中的氟康唑耐药性（46.5%）比白色念珠菌（36.8%）或光滑念珠菌（30.8%）更常见。提供药敏不同菌株的患者在人口统计学特征或基础疾病方面没有显著差异。
