Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Gastroenterol Clin North Am. 2013 Jun;42(2):285-98. doi: 10.1016/j.gtc.2013.01.006. Epub 2013 Mar 6.
Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.
幽门螺杆菌感染会引起慢性炎症，是已知的最强胃癌风险因素。幽门螺杆菌的基因组高度多样化，因此细菌的毒力因子在确定幽门螺杆菌感染的结果方面起着重要作用，这与宿主反应相结合，宿主反应会受到环境和饮食风险因素的增强。深入了解幽门螺杆菌感染的发病机制对于开发针对这种常见但致命恶性肿瘤的更有效治疗方法非常重要。本文综述重点关注了幽门螺杆菌用于驱动胃癌发生的特定机制。
