Su Lan, Yang Rui, Sheng Yanan, Ullah Saif, Zhao Yuheng, Shunjiayi Hu, Zhao Zhuo, Wang Qingjing
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
Department of Microbiology School of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Front Microbiol. 2024 May 2;15:1369834. doi: 10.3389/fmicb.2024.1369834. eCollection 2024.
The oral cavity stands as one of the pivotal interfaces facilitating the intricate interaction between the human body and the external environment. The impact of diverse oral microorganisms on the emergence and progression of various systemic cancers, typified by oral cancer, has garnered increasing attention. The potential pathogenicity of oral bacteria, notably the anaerobic and , has been extensively studied and exhibits obvious correlation with different carcinoma types. Furthermore, oral fungi and viruses are closely linked to oropharyngeal carcinoma. Multiple potential mechanisms of oral microbiota-induced carcinogenesis have been investigated, including heightened inflammatory responses, suppression of the host immune system, influence on the tumor microenvironment, anti-apoptotic activity, and promotion of malignant transformation. The disturbance of microbial equilibrium and the migration of oral microbiota play a pivotal role in facilitating oncogenic functions. This review aims to comprehensively outline the pathogenic mechanisms by which oral microbiota participate in carcinogenesis. Additionally, this review delves into their potential applications in cancer prevention, screening, and treatment. It proves to be a valuable resource for researchers investigating the intricate connection between oral microbiota and systemic cancers.
口腔是促进人体与外部环境复杂相互作用的关键界面之一。多种口腔微生物对以口腔癌为代表的各种全身性癌症的发生和发展的影响日益受到关注。口腔细菌的潜在致病性，尤其是厌氧菌和 ，已得到广泛研究，并且与不同的癌症类型呈现出明显的相关性。此外，口腔真菌和病毒与口咽癌密切相关。已经研究了口腔微生物群诱导致癌的多种潜在机制，包括增强炎症反应、抑制宿主免疫系统、影响肿瘤微环境、抗凋亡活性以及促进恶性转化。微生物平衡的紊乱和口腔微生物群的迁移在促进致癌功能方面起着关键作用。本综述旨在全面概述口腔微生物群参与致癌作用的致病机制。此外，本综述还深入探讨了它们在癌症预防、筛查和治疗中的潜在应用。对于研究口腔微生物群与全身性癌症之间复杂联系的研究人员来说，它被证明是一份有价值的资源。
