Silberberg Gilad
Department of Neuroscience, Karolinska institute, Stockholm 17177, Sweden.
Curr Opin Neurobiol. 2008 Jun;18(3):332-7. doi: 10.1016/j.conb.2008.08.009.
Inhibitory pathways in the neocortex display a variety of temporal and spatial patterns, maintaining a dynamic balance with excitatory synaptic activity. Recent studies have revealed prevalent polysynaptic subcircuits within the neocortical microcircuitry. These subcircuits involve excitatory and inhibitory connections that are activated by neurons both in supragranular and infragranular cortical layers and mediated by different mechanisms. Interestingly, in these subcircuits inhibition is induced by discharge of pyramidal cells, and excitation is caused by specific types of GABAergic interneurons. The different polysynaptic subcircuits are discussed with respect to their spatial and temporal properties and their possible functional role in cortical processing.
新皮层中的抑制性通路呈现出多种时间和空间模式，与兴奋性突触活动保持动态平衡。最近的研究揭示了新皮层微回路中普遍存在的多突触子回路。这些子回路涉及由颗粒上层和颗粒下层皮质层中的神经元激活并由不同机制介导的兴奋性和抑制性连接。有趣的是，在这些子回路中，抑制是由锥体细胞的放电诱导的，而兴奋是由特定类型的GABA能中间神经元引起的。本文讨论了不同多突触子回路的空间和时间特性及其在皮质处理中可能的功能作用。
