壳聚糖/聚乙二醇二丙烯酸酯薄膜作为潜在的伤口敷料材料。
Chitosan/polyethylene glycol diacrylate films as potential wound dressing material.
作者信息
Zhang Xiaodan, Yang Dongzhi, Nie Jun
机构信息
State Key Laboratory of Chemical Resource Engineering, Key Lab of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
出版信息
Int J Biol Macromol. 2008 Dec;43(5):456-62. doi: 10.1016/j.ijbiomac.2008.08.010. Epub 2008 Sep 3.
Michael addition reaction of Chitosan (CS) and polyethylene glycol diacrylate (PEGDA) was carried out successfully in acidic solution. Films with CS/PEGDA weight ratios from 100/0 to 0/100 in 10% increments were analyzed by Fourier transform infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and X-Ray Diffraction (XRD). Additionally, the films were characterized by measuring mechanical property, swelling property. The potential application of the CS/PEGDA film as wound dressing material was evaluated in vitro by using mouse fibroblasts (L929) as reference cell lines, indirect cytotoxicity assessment indicated that CS/PEGDA films were nontoxic to L929 cell.
壳聚糖（CS）与聚乙二醇二丙烯酸酯（PEGDA）在酸性溶液中成功进行了迈克尔加成反应。采用傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和X射线衍射（XRD）对CS/PEGDA重量比从100/0到0/100（以10%递增）的薄膜进行了分析。此外，通过测量机械性能、溶胀性能对薄膜进行了表征。以小鼠成纤维细胞（L929）作为参照细胞系，在体外评估了CS/PEGDA薄膜作为伤口敷料材料的潜在应用，间接细胞毒性评估表明CS/PEGDA薄膜对L929细胞无毒。
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