Musti Marina, Pollice Alessio, Cavone Domenica, Dragonieri Silvano, Bilancia Massimo
Department of Internal Medicine and Public Medicine, Section of Occupational Medicine Ramazzini, University of Bari, National Register of Mesothelioma, Regional Operative Centre (C.O.R.), Apulia, Italy.
Int Arch Occup Environ Health. 2009 Mar;82(4):489-97. doi: 10.1007/s00420-008-0358-5. Epub 2008 Sep 23.
To estimate the mesothelioma risk and environmental asbestos exposure (EAE) due to an asbestos-cement plant.
A spatial case-control study including 48 malignant mesothelioma (MM) cases occurred in the period 1993-2003 selected from the regional mesothelioma register (RMR) and 273 controls. The disease risk was estimated by means of a logistic-regression model, in which the probability of disease-occurrence is expressed as a function of the classes of distances. A non-parametric method was applied to estimate the full relative risk surface.
Significant MM odds ratio of 5.29 (95 CI: 1.18-23.74) was found for people living within a range up to 500 m centered on the plant. The non-parametric estimation of relative risk surface unveiled a marked peak near the plant not paralleled by the spatial distribution of controls.
Evidence of an association between mesothelioma risk and EAE is highlighted. The role played by the RMR in increasing the public health local authorities awareness is stressed.
评估一家石棉水泥厂导致间皮瘤的风险及环境石棉暴露情况。
一项空间病例对照研究，纳入了1993年至2003年间从地区间皮瘤登记处（RMR）选取的48例恶性间皮瘤（MM）病例以及273名对照。通过逻辑回归模型估计疾病风险，其中疾病发生的概率表示为距离类别的函数。应用非参数方法估计完整的相对风险表面。
在以该厂为中心半径500米范围内居住的人群中，发现显著的MM优势比为5.29（95%置信区间：1.18 - 23.74）。相对风险表面的非参数估计显示该厂附近有一个明显的峰值，而对照的空间分布与之并不平行。
强调了间皮瘤风险与环境石棉暴露之间关联的证据。强调了RMR在提高地方公共卫生当局意识方面所起的作用。
