Xin Huawei, Liu Dan, Songyang Zhou
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA.
Genome Biol. 2008;9(9):232. doi: 10.1186/gb-2008-9-9-232. Epub 2008 Sep 18.
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions.
位于真核生物染色体末端的端粒在保护染色体末端以及调节细胞增殖的细胞内信号传导方面发挥着双重作用。一种由六种端粒相关蛋白组成的复合物已被鉴定出来——端粒体或端粒保护蛋白复合物——它对于端粒结构的维持及其信号传导功能都至关重要。
