Ayata A, Tatlipinar S, Kar T, Unal M, Ersanli D, Bilge A H
Department of Ophthalmology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Uskudar, Istanbul, Turkey.
Br J Ophthalmol. 2009 Jan;93(1):79-82. doi: 10.1136/bjo.2008.141564. Epub 2008 Oct 1.
The aim of the study was to compare the results of short-wavelength (SW) and near-infrared (NIR) autofluorescence (AF) in acute central serous chorioretinopathy (CSC).
Twenty-six eyes of the 26 patients diagnosed with CSC (mean age 37.4 years) were included in this retrospective study. AF images were evaluated and compared with angiographic and ophthalmoscopic findings. Fluorescein angiography and AF imaging were performed using a confocal scanning laser ophthalmoscope.
Focally decreased AF at the leakage site was seen in most of the cases with acute CSC (20 of 26 eyes in SW-AF; 20 of 20 eyes in NIR-AF). Twenty-four of the 26 cases had decreased SW-AF corresponding to the area of the serous retinal detachment, while 19 of the available 20 cases had decreased NIR-AF corresponding to the area of the serous retinal detachment. Increased granular AF corresponding to the extent of the former retinal detachment was seen earlier with SW-AF imaging, but disappeared later in the course of disease with NIR-AF imaging.
AF imaging in CSC demonstrates different patterns according to the course of the disease, reflecting RPE and outer retinal changes. Combining two different methods of AF imaging could predict recent or former CSC episodes and may be a non-invasive technique for monitoring CSC and performing differential diagnosis.
本研究旨在比较急性中心性浆液性脉络膜视网膜病变（CSC）中短波长（SW）和近红外（NIR）自发荧光（AF）的结果。
本回顾性研究纳入了26例诊断为CSC的患者的26只眼（平均年龄37.4岁）。对AF图像进行评估，并与血管造影和检眼镜检查结果进行比较。使用共焦扫描激光检眼镜进行荧光素血管造影和AF成像。
在大多数急性CSC病例中，可见渗漏部位的局灶性AF降低（SW-AF中26只眼中的20只；NIR-AF中20只眼中的20只）。26例中有24例SW-AF降低对应于浆液性视网膜脱离区域，而20例中19例可用的NIR-AF降低对应于浆液性视网膜脱离区域。与先前视网膜脱离范围相对应的颗粒状AF增加在SW-AF成像中更早出现，但在疾病过程中随着NIR-AF成像而消失得更晚。
CSC中的AF成像根据疾病进程显示出不同模式，反映了视网膜色素上皮（RPE）和视网膜外层的变化。结合两种不同的AF成像方法可以预测近期或既往的CSC发作，可能是一种用于监测CSC和进行鉴别诊断的非侵入性技术。
