Rogers K S, Komkov A, Brown S A, Lees G E, Hightower D, Russo E A
Department of Small Animal Medicine, College of Veterinary Medicine, Texas A&M University, College Station 77843-4474.
Am J Vet Res. 1991 Jun;52(6):961-4.
Four methods of evaluating renal function were performed in 6 cats anesthetized with halothane in oxygen. Glomerular filtration rate (GFR) was measured simultaneously in each cat by exogenous creatinine clearance (ECC), bolus inulin clearance, and 99mTc(Sn)-diethylene-triaminepentaacetic acid (DTPA) clearance determined by 2 different methods. In the first DTPA clearance method (DTPA-1), we measured radioactivity in serial blood specimens to construct plasma disappearance curves for calculation of GFR. In the second DTPA clearance method (DTPA-2), we used serial external head counts of radioactivity and a single blood specimen to construct plasma disappearance curves for calculation of GFR. Bolus inulin clearance was calculated from plasma disappearance curves using a 1-compartment open pharmacokinetic model (IN-1) and a 2-compartment open pharmacokinetic model (IN-2). Glomerular filtration rates were measured over 3 hours, for creatinine and DTPA methods, and over 4 hours for the inulin methods. The GFR obtained with the reference method (ECC) was 2.56 +/- 0.61 ml/min/kg of body weight (mean +/- SD). Values for GFR determined by ECC and DTPA-1 were significantly correlated (r = 0.852; P less than or equal to 0.05). Correlation between ECC and DTPA 2 was not as good (r = 0.783; P less than or equal to 0.10), but the 2 DTPA methods significantly correlated with one another (r = 0.897; P less than or equal to 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
对6只吸入氧气和氟烷麻醉的猫进行了四种评估肾功能的方法。通过外源性肌酐清除率（ECC）、大剂量菊粉清除率以及用两种不同方法测定的99mTc（Sn）-二乙三胺五乙酸（DTPA）清除率，同时测量每只猫的肾小球滤过率（GFR）。在第一种DTPA清除率方法（DTPA-1）中，我们测量连续血标本中的放射性，构建血浆消失曲线以计算GFR。在第二种DTPA清除率方法（DTPA-2）中，我们使用连续的放射性头部外部计数和单个血标本构建血浆消失曲线以计算GFR。大剂量菊粉清除率通过使用一室开放药代动力学模型（IN-1）和二室开放药代动力学模型（IN-2）从血浆消失曲线计算得出。肌酐和DTPA方法的GFR测量3小时，菊粉方法测量4小时。参考方法（ECC）获得的GFR为2.56±0.61 ml/（min·kg体重）（平均值±标准差）。ECC和DTPA-1测定的GFR值显著相关（r = 0.852；P≤0.05）。ECC和DTPA 2之间的相关性没那么好（r = 0.783；P≤0.10），但两种DTPA方法彼此显著相关（r = 0.
