鉴定一名乌干达血统个体中的 HLA-DPA1*020107。

Identification of HLA-DPA1*020107 in an individual of Ugandan descent.

机构信息

National Microbiology Laboratory, Winnipeg, Manitoba, Canada.

出版信息

Hum Immunol. 2010 Jul;71(7):733-5. doi: 10.1016/j.humimm.2010.05.003. Epub 2010 May 12.

DOI:10.1016/j.humimm.2010.05.003

PMID:20470845

Abstract

DPA1020107 was identified from a woman of Ugandan origin by a taxonomy-based sequence analysis of human leukocyte antigen DPA1. The new allele was confirmed by cloning and sequencing of the polymerase chain reaction products. It is identical to DPA1020101 with the exception of a single nucleotide synonymous substitution at codon 58 (GGC-->GGT). The World Health Organization Nomenclature Committee has named the allele as DPA1*020107.

摘要

通过对人类白细胞抗原 DPA1 的基于分类的序列分析，从一名乌干达血统的女性中鉴定出 DPA1020107。通过聚合酶链反应产物的克隆和测序确认了新等位基因。它与 DPA1020101 完全相同，除了密码子 58 处的单个核苷酸同义取代（GGC-->GGT）。世界卫生组织命名委员会将该等位基因命名为 DPA1*020107。