Zhu Jin Liang, Basso Olga, Obel Carsten, Bech Bodil Hammer, Nohr Ellen Aagaard, Shrestha Anshu, Olsen Jørn
The Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark.
Hum Reprod. 2009 Feb;24(2):445-50. doi: 10.1093/humrep/den366. Epub 2008 Oct 7.
The reproductive health of children born of infertile couples may be affected by infertility treatment or factors associated with infertility. We examined sexual maturation in children of parents with infertility.
We used data from a follow-up of 3382 girls and 2810 boys born between 1984 and 1987 in the Aalborg-Odense Birth Cohort. We had mothers' report of time to pregnancy (TTP) and infertility treatment (at the time, mostly hormonal) from the pregnancy questionnaire administered in 1984-1987, and the children's report of their own sexual maturation from the follow-up questionnaire administered in 2005, when they were between 18 and 21 years old. Many reported age only in year when they had the events related to sexual maturation, and for each event, we imputed the month based on the median month at each year of age among those reporting both years and months.
In girls, the mean age at menarche was 13.3 years and, in boys, the mean age at appearance of acne, voice break, regular shaving and first nocturnal emission were 14.5, 14.5, 17.2 and 14.7 years, respectively. We saw no significant differences in age at these events among children born of either fertile (with TTP of 0-12 months and no treatment), untreated infertile (with TTP of more than 12 months and no treatment) or treated infertile couples (with a history of examination or treatment for infertility).
Our data suggest no significant association between parental infertility or hormonal treatment and timing of sexual maturation in the offspring.
不孕夫妇所生孩子的生殖健康可能会受到不孕治疗或与不孕相关因素的影响。我们研究了不孕父母所生孩子的性成熟情况。
我们使用了奥尔堡 - 欧登塞出生队列中1984年至1987年间出生的3382名女孩和2810名男孩的随访数据。我们从1984 - 1987年进行的妊娠问卷中获取了母亲关于怀孕时间（TTP）和不孕治疗（当时主要是激素治疗）的报告，以及从2005年进行的随访问卷中获取了孩子们关于自身性成熟的报告，当时他们年龄在18至21岁之间。许多人只报告了与性成熟相关事件发生的年份，对于每个事件，我们根据报告了年份和月份的人群中各年龄的中位数月份来推算月份。
女孩月经初潮的平均年龄为13.3岁，男孩出现痤疮、变声、开始定期剃须和首次遗精的平均年龄分别为14.5岁、14.5岁、17.2岁和14.7岁。在生育能力正常（TTP为0 - 12个月且未接受治疗）、未经治疗的不孕（TTP超过12个月且未接受治疗）或接受过治疗的不孕夫妇（有不孕检查或治疗史）所生孩子中，这些事件的发生年龄没有显著差异。
我们的数据表明，父母的不孕或激素治疗与后代性成熟时间之间没有显著关联。
