Crawford W H, Houge J C, Neirby D T, Di Mino A, Di Mino A A
Department of Surgical Science, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
Can J Vet Res. 1991 Jan;55(1):76-85.
The effect of pulsed radio frequency therapy (PRFT) was evaluated on seven ponies with no arthritis and in 28 ponies in which arthritis was created using intra-articular amphotericin B to induce synovitis in the right middle carpal joint. The ponies were divided into five treatment and two control groups. Two levels of arthritis were created and two dosage levels of PRFT were evaluated. The effect of PRFT on arthritic and nonarthritic joints was measured by comparing synovial fluid parameters, the degree and duration of lameness, the range of carpal motion, and carpus circumference, for treated and untreated groups. Lesions seen radiographically, at gross pathology, and by histopathology were also compared between the treated and control groups. In the ponies with a mild form of induced arthritis, PRFT significantly (p less than 0.05) reduced the severity and duration of lameness, swelling of the carpus, and the severity of gross pathological and radiographic changes. In these ponies the synovial acid phosphatase levels were lower, the mucin clot quality was superior, and the synovial protein levels were lower for the ponies receiving PRFT as compared to the arthritic ponies receiving no treatment. A dose response effect was evident. In ponies with a slightly more severe form of arthritis, PRFT was evaluated at one dosage level. The treated ponies were significantly improved over the untreated ponies with respect to carpal range of motion, degree of lameness, carpus swelling, and radiographic lesions. No deleterious effects were noted when normal, PRFT treated, middle carpal joints were compared to contralateral untreated, normal joints. It was concluded that significant beneficial effects resulted when affected ponies were treated with PRFT.
对7匹无关节炎的小马以及28匹通过关节内注射两性霉素B诱发右腕中关节滑膜炎而患关节炎的小马，评估了脉冲射频疗法（PRFT）的效果。这些小马被分为5个治疗组和2个对照组。制造了两种程度的关节炎，并评估了两种PRFT剂量水平。通过比较治疗组和未治疗组的滑液参数、跛行程度和持续时间、腕关节活动范围以及腕围，来衡量PRFT对患关节炎和未患关节炎关节的影响。还比较了治疗组和对照组在X线片、大体病理学和组织病理学上所见的病变。在轻度诱发关节炎的小马中，PRFT显著（p小于0.05）降低了跛行的严重程度和持续时间、腕关节肿胀以及大体病理和X线变化的严重程度。与未接受治疗的患关节炎小马相比，接受PRFT治疗的小马滑液酸性磷酸酶水平较低，粘蛋白凝块质量较好，滑液蛋白水平较低。有明显的剂量反应效应。在关节炎稍严重一些的小马中，对PRFT在一个剂量水平进行了评估。在腕关节活动范围、跛行程度、腕关节肿胀和X线病变方面，治疗后的小马比未治疗的小马有显著改善。当将接受PRFT治疗的正常腕中关节与对侧未治疗的正常关节进行比较时，未发现有害影响。得出的结论是，用PRFT治疗患病小马会产生显著的有益效果。
