Sjöberg F, Gustafsson U, Lewis D H
Department of Anesthesiology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Circ Shock. 1991 Jul;34(3):319-28.
Tissue pO2 (ptO2) and pH (ptH) in skeletal muscle are known to be affected at an early stage of hemorrhage. This study examines the effects of hypovolemia on the extracellular ptO2 and ptH distributions at multiple tissue sites using a recently developed multipoint microelectrode, that provides simultaneous measurements of ptO2 and ptH. The results show that the development of tissue acidosis occurs in spatially different patterns and that the magnitude of the acidosis at some tissue sites is larger and remains longer than previously known. The changes described are believed to be due to the heterogeneous blood flow seen during shock and after reperfusion. The degree of local acidosis was correlated to the relative decrease in oxygen tension at that particular site. These new findings can be of importance for the development of future resuscitative measures as well as in constructing patient monitoring systems.
已知骨骼肌中的组织氧分压（ptO2）和pH值（ptH）在出血早期会受到影响。本研究使用最近开发的多点微电极，研究低血容量对多个组织部位细胞外ptO2和ptH分布的影响，该微电极可同时测量ptO2和ptH。结果表明，组织酸中毒的发展呈现出空间上不同的模式，并且某些组织部位的酸中毒程度比以前所知的更大且持续时间更长。据信所描述的这些变化是由于休克期间和再灌注后出现的血流不均一性所致。局部酸中毒的程度与该特定部位氧张力的相对降低相关。这些新发现对于未来复苏措施的发展以及构建患者监测系统可能具有重要意义。
