Anderson M J
Infect Immun. 1978 Jun;20(3):608-12. doi: 10.1128/iai.20.3.608-612.1978.
The presence in the spleens of unsensitized CBA mice of cells that are spontaneously cytotoxic for Sendai virus-infected L cells was confirmed. This innate cytotoxic activity to virus-infected cells was shown to exhibit some H-2 restriction. Partial identity of only the D end of the H-2 gene complex between the target and effector cells was required to produce cytolysis. Attempts to characterize the kind of cell active in this system indicated that neither the theta antigen nor the surface immunoglobulin markers were present. Furthermore, the cells appeared to have no adherent or phagocytic properties. The relationship between the effector cells responsible for innate cytotoxicity to virus-infected cells and the natural killer (NK) cells spontaneously cytotoxic for certain tumor cells is discussed.
已证实在未致敏的CBA小鼠脾脏中存在对仙台病毒感染的L细胞具有自发细胞毒性的细胞。这种对病毒感染细胞的先天性细胞毒性活性表现出一些H-2限制性。靶细胞和效应细胞之间仅H-2基因复合体的D端部分相同，即可产生细胞溶解。对该系统中活性细胞类型进行表征的尝试表明，既不存在θ抗原，也不存在表面免疫球蛋白标志物。此外，这些细胞似乎没有黏附或吞噬特性。本文讨论了对病毒感染细胞具有先天性细胞毒性的效应细胞与对某些肿瘤细胞具有自发细胞毒性的自然杀伤（NK）细胞之间的关系。
