Budowsky E I, Friedman E A, Zheleznova N V, Noskov F S
N.D. Zelinsky Institute of Organic Chemistry, USSR Academy of Sciences, Moscow.
Vaccine. 1991 Jun;9(6):398-402. doi: 10.1016/0264-410x(91)90125-p.
The kinetics of inactivation of the infectivity of the influenza virus by beta-propiolactone have been studied. Rate constants have been determined for inactivation of the A/Leningrad/385 (H3N2) and B/Leningrad/489/80 influenza virus under the action of beta-propiolactone on a virus-containing allantoic fluid and on a purified viral suspension. The data obtained allow calculation of the time required for inactivation of the influenza virus infectivity to a given extent in virus-containing solutions at any initial concentration of beta-propiolactone.
已对β-丙内酯使流感病毒感染性失活的动力学进行了研究。已测定了在β-丙内酯作用下，A/列宁格勒/385（H3N2）和B/列宁格勒/489/80流感病毒在含病毒尿囊液和纯化病毒悬液中的失活速率常数。所获得的数据使得能够计算在任何初始浓度的β-丙内酯下，含病毒溶液中流感病毒感染性失活到给定程度所需的时间。
